CTL2 Antibody (F7): sc-101266

CTL2 Antibody (F7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CTL2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CTL2 antibody (F7) is available as the non-conjugated form. CTL2, also known as SLC44A2 (solute carrier family 44 member 2), is a multi-pass membrane protein primarily located in the inner ear, where CTL2 plays a crucial role in choline transport, an essential nutrient necessary for acetylcholine and phosphatidylcholine synthesis. CTL2 function is vital, as choline cannot freely cross cell membranes, and choline transport is critical for maintaining cellular health and function. Deficiencies in choline transport can lead to significant cellular dysfunction, contributing to conditions such as autoimmune hearing loss and neurodegenerative diseases like Alzheimer′s and Parkinson′s. Through facilitating choline movement across cell membranes, CTL2 helps ensure adequate cellular levels of this important nutrient, supporting processes such as neurotransmission and membrane integrity.

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CTL2 Antibody (F7) References:

1. An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins.  |  O'Regan, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 1835-40. PMID: 10677542
2. Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss.  |  Nair, TS., et al. 2004. J Neurosci. 24: 1772-9. PMID: 14973250
3. Molecular characterization of the family of choline transporter-like proteins and their splice variants.  |  Traiffort, E., et al. 2005. J Neurochem. 92: 1116-25. PMID: 15715662
4. Choline transport for phospholipid synthesis.  |  Michel, V., et al. 2006. Exp Biol Med (Maywood). 231: 490-504. PMID: 16636297
5. DFNB68, a novel autosomal recessive non-syndromic hearing impairment locus at chromosomal region 19p13.2.  |  Santos, RL., et al. 2006. Hum Genet. 120: 85-92. PMID: 16703383
6. Choline transporters in human lung adenocarcinoma: expression and functional implications.  |  Wang, T., et al. 2007. Acta Biochim Biophys Sin (Shanghai). 39: 668-74. PMID: 17805461
7. Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear.  |  Kommareddi, PK., et al. 2007. J Assoc Res Otolaryngol. 8: 435-46. PMID: 17926100
8. Autoantibodies to recombinant human CTL2 in autoimmune hearing loss.  |  Kommareddi, PK., et al. 2009. Laryngoscope. 119: 924-32. PMID: 19319905
9. Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2.  |  Kommareddi, PK., et al. 2010. Protein J. 29: 417-26. PMID: 20665236
10. Age-related changes in expression of CTL2/SLC44A2 and its isoforms in the mouse inner ear.  |  Beyer, LA., et al. 2011. Hear Res. 282: 63-8. PMID: 21986210
11. Expression of the CTL2 transcript variants in human peripheral blood cells and human tissues.  |  Flesch, BK., et al. 2013. Transfusion. 53: 3217-23. PMID: 23480595
12. Non-invasive prenatal testing for fetal Ss, Kidd, and CTL2 blood group prediction by multiplex digital droplet PCR.  |  Wang, Y., et al. 2023. Ther Adv Hematol. 14: 20406207231179334. PMID: 37575175

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CTL2 Antibody (F7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CTL2 Antibody (F7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CTL2 Antibody (F7) Specifications

Alternate Product Name: CTL2

Product Clone Name: F7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 123-231

Epitope Target: CTL2

Epitope Species: human

Product Reactivity/Detection: CTL2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CTL2 Antibody (F7): N/A