CtBP Antibody (C-1): sc-17805
- CtBP Antibody (C-1) is a mouse monoclonal IgG2b κ, cited in 12 publications, provided at 200 µg/ml
- raised against amino acids 1-440 of CtBP1 of human origin
- recommended for detection of CtBP1 and CtBP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See CtBP (E-12): sc-17759 for CtBP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CtBP Antibody (C-1) for WB and IHC(P) applications. These reagents are now offered in bundles with CtBP Antibody (C-1) (see ordering information below).
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CtBP Antibody (C-1) is a mouse monoclonal IgG2b antibody that detects CtBP1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CtBP1 is a crucial cellular phosphoprotein that functions as a corepressor of transcription, particularly in regulating gene expression during development and cellular differentiation. CtBP1 interacts with various proteins, including breast cancer gene BRCA1 through CtIP protein, highlighting CtBP1′s importance in cellular processes, especially in DNA damage response. CtBP1-CtIP interaction inhibits p21 promoter transactivation, regulating p21 transcription essential for maintaining cellular integrity and preventing oncogenesis. CtBP1 expression spans from embryonic stages to adulthood, underscoring CtBP1′s fundamental role in both developmental and adult tissues. anti-CtBP1 antibody (C-1) serves as a valuable tool for researchers investigating gene regulation mechanisms and CtBP1′s implications in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CtBP Antibody (C-1) References:
- CtBP, an unconventional transcriptional corepressor in development and oncogenesis. | Chinnadurai, G. 2002. Mol Cell. 9: 213-24. PMID: 11864595
- The multiple activities of CtBP/BARS proteins: the Golgi view. | Corda, D., et al. 2006. Trends Cell Biol. 16: 167-73. PMID: 16483777
- The transcriptional corepressor CtBP: a foe of multiple tumor suppressors. | Chinnadurai, G. 2009. Cancer Res. 69: 731-4. PMID: 19155295
- ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. | Li, L., et al. 2017. Nat Commun. 8: 691. PMID: 28947780
- CtBP represses Dpp signaling as a dimer. | Bi, C., et al. 2018. Biochem Biophys Res Commun. 495: 1980-1985. PMID: 29225171
- CPP-E1A fusion peptides inhibit CtBP-mediated transcriptional repression. | Blevins, MA., et al. 2018. Mol Oncol. 12: 1358-1373. PMID: 29879296
- CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling. | Zhao, Z., et al. 2019. Oncogene. 38: 2076-2091. PMID: 30442980
- Inhibition of CtBP-Regulated Proinflammatory Gene Transcription Attenuates Psoriatic Skin Inflammation. | Li, H., et al. 2022. J Invest Dermatol. 142: 390-401. PMID: 34293351
- CtBP Neuroprotective Role in Toxin-Based Parkinson's Disease Models: From Expression Pattern to Dopaminergic Survival. | Saraiva, C., et al. 2023. Mol Neurobiol. 60: 4246-4260. PMID: 37060501
- A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor. | Raicu, AM., et al. 2024. J Biol Chem. 300: 105490. PMID: 38000659
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CtBP Antibody (C-1) | sc-17805 | 200 µg/ml | $322.00 | |||
CtBP Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-536590 | 200 µg Ab; 10 µg BP | $361.00 | |||
CtBP Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-533741 | 200 µg Ab; 40 µg BP | $361.00 |