Csk Antibody (CSK-04): sc-51580
- Csk Antibody (CSK-04) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µl
- raised against bacterially expressed recombinant fragment, corresponding to amino acids 330-450 of human Csk
- recommended for detection of Csk of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Csk Antibody (CSK-04). This work is in progress.
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SEE ALSO...
Csk Antibody (CSK-04) is a mouse monoclonal IgG1 antibody that detects Csk in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Csk, or C-terminal Src kinase, plays a crucial role in regulating the activity of Src family tyrosine kinases, which are essential for various cellular processes, including proliferation, differentiation, and survival. By phosphorylating Src on the tyrosine residue Y527, Csk effectively downregulates Src activity, thereby maintaining cellular homeostasis and preventing uncontrolled cell growth. This regulatory mechanism is particularly important in the context of cancer, where aberrant Src activity can lead to tumorigenesis. Additionally, Csk interacts with other Src family kinases such as Lyn, Fyn, and Lck, modulating their activity through similar phosphorylation events. The ability of Csk to fine-tune the signaling pathways involving these kinases underscores its significance in cellular signaling and its potential as a therapeutic target in diseases characterized by Src overactivity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Csk Antibody (CSK-04) References:
- C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases. | Chong, YP., et al. 2005. Growth Factors. 23: 233-44. PMID: 16243715
- Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases. | Ia, KK., et al. 2010. Growth Factors. 28: 329-50. PMID: 20476842
- Csk regulates angiotensin II-induced podocyte apoptosis. | Zhang, L., et al. 2016. Apoptosis. 21: 846-55. PMID: 27225249
- SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding. | Brian, BF., et al. 2022. Sci Rep. 12: 5875. PMID: 35393453
- Apoptosis regulation by the tyrosine-protein kinase CSK. | Fortner, A., et al. 2022. Front Cell Dev Biol. 10: 1078180. PMID: 36578781
- Dissection of the catalytic and regulatory structure-function relationships of Csk protein tyrosine kinase. | Sun, G. and Ayrapetov, MK. 2023. Front Cell Dev Biol. 11: 1148352. PMID: 36936693
- Regulation, targets and functions of CSK. | Zhu, S., et al. 2023. Front Cell Dev Biol. 11: 1206539. PMID: 37397251
- CSK-mediated signalling by integrins in cancer. | Maldonado, H. and Leyton, L. 2023. Front Cell Dev Biol. 11: 1214787. PMID: 37519303
- CSK may be a potential prognostic biomarker reflecting the immune status of gastric cancer. | Yan, X. and Huan, J. 2024. Eur Rev Med Pharmacol Sci. 28: 221-230. PMID: 38235873
- Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation. | Inoue, T., et al. 2024. J Exp Med. 221: PMID: 38753246
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Csk Antibody (CSK-04) | sc-51580 | 100 µl | $322.00 |