CSA Antibody (D-2): sc-376981

CSA Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CSA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CSA (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CSA protein plays a crucial role in the nucleotide excision repair pathway, specifically in the preferential repair of DNA lesions on the transcribed strand of active genes, a process vital for maintaining genomic stability and preventing mutations that can lead to diseases such as cancer. This preferential repair mechanism is directed by CSA and its homolog CSB, which work together to ensure that the DNA template strand is repaired more efficiently than the non-transcribed strand. Mutations in CSA gene are associated with Cockayne′s syndrome, a disorder characterized by sensitivity to ultraviolet light and developmental defects, highlighting CSA′s importance in cellular response to DNA damage. CSA protein is classified within the "WD-repeat" family, known for its role in protein-protein interactions, further emphasizing CSA′s significance in cellular repair processes.

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CSA Antibody (D-2) References:

1. ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.  |  Troelstra, C., et al. 1992. Cell. 71: 939-53. PMID: 1339317
2. Cross-sectional area and muscular strength: a brief review.  |  Jones, EJ., et al. 2008. Sports Med. 38: 987-94. PMID: 19026016
3. Clinical utility of cyclosporine (CsA) ophthalmic emulsion 0.05% for symptomatic relief in people with chronic dry eye: a review of the literature.  |  Rhee, MK. and Mah, FS. 2017. Clin Ophthalmol. 11: 1157-1166. PMID: 28790800
4. In Vitro Activities of the Cationic Steroid Antibiotics CSA-13, CSA-131, CSA-138, CSA-142, and CSA-192 Against Carbapenem-resistant Pseudomonas aeruginosa.  |  Bozkurt Güzel, Ç., et al. 2020. Turk J Pharm Sci. 17: 63-67. PMID: 32454762
5. Cyclosporine A: Chemistry and Toxicity - A Review.  |  Patocka, J., et al. 2021. Curr Med Chem. 28: 3925-3934. PMID: 33023428
6. Critical shoulder angle (CSA): age and gender distribution in the general population.  |  Gumina, S., et al. 2022. J Orthop Traumatol. 23: 10. PMID: 35157156
7. A non-toxic recombinant bivalent chimeric protein rETXm3CSAm4/TMD as a potential vaccine candidate against enterotoxemia and braxy.  |  Du, J., et al. 2023. Vaccine. 41: 1232-1238. PMID: 36635138
8. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.  |  Henning, KA., et al. 1995. Cell. 82: 555-64. PMID: 7664335
9. Structure and expression of the excision repair gene ERCC6, involved in the human disorder Cockayne's syndrome group B.  |  Troelstra, C., et al. 1993. Nucleic Acids Res. 21: 419-26. PMID: 8382798
10. Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.  |  Iyer, N., et al. 1996. Biochemistry. 35: 2157-67. PMID: 8652557
11. The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.  |  van Gool, AJ., et al. 1997. EMBO J. 16: 5955-65. PMID: 9312053
12. RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.  |  Tantin, D. 1998. J Biol Chem. 273: 27794-9. PMID: 9774388

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CSA Antibody (D-2) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CSA Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CSA Antibody (D-2) Specifications

Alternate Product Name: CSA

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 131-396

Epitope Target: CSA

Epitope Species: human

Product Reactivity/Detection: CSA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CSA Antibody (D-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin