Crossveinless-2 Antibody (G-8): sc-377502
- Crossveinless-2 Antibody (G-8) is a mouse monoclonal IgG1 κ Crossveinless-2 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 497-685 mapping at the C-terminus of Crossveinless-2 of human origin
- Crossveinless-2 Antibody (G-8) is recommended for detection of Crossveinless-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Crossveinless-2 Antibody (G-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Crossveinless-2 Antibody (G-8) for WB applications. These reagents are now offered in bundles with Crossveinless-2 Antibody (G-8) (see ordering information below).
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Crossveinless-2 Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Crossveinless-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Crossveinless-2 antibody (G-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Crossveinless-2, also known as BMP-binding endothelial regulator protein, Cvl2, or Cv2, is a member of the Chordin family and plays a crucial role in regulating bone morphogenetic protein (BMP) signaling during embryonic development. Crossveinless-2 is primarily secreted and is characterized by a unique structure, which includes a trypsin inhibitory-like (TIL) domain, five von Willebrand factor type C (VWFC) domains, and one von Willebrand factor type D (VWFD) domain. These domains facilitate Crossveinless-2′s interaction with BMPs, particularly BMP4 and BMP2, allowing modulation of BMP signaling pathways effectively. Through binding to these ligands, Crossveinless-2 can either enhance or inhibit BMP signaling, thereby influencing critical developmental processes. Expression occurs at sites of high BMP activity, providing a feedback mechanism essential for proper embryonic development. Crossveinless-2′s ability to aid in ligand transport further underscores importance in maintaining BMP homeostasis, making Crossveinless-2 a vital component in the intricate network of signaling pathways that govern cellular differentiation and tissue formation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Crossveinless-2 Antibody (G-8) References:
- Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling. | Coffinier, C., et al. 2002. Gene Expr Patterns. 2: 189-94. PMID: 12617799
- Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. | Binnerts, ME., et al. 2004. Biochem Biophys Res Commun. 315: 272-80. PMID: 14766204
- Vertebrate crossveinless 2 is secreted and acts as an extracellular modulator of the BMP signaling cascade. | Kamimura, M., et al. 2004. Dev Dyn. 230: 434-45. PMID: 15188429
- A vertebrate crossveinless 2 homologue modulates BMP activity and neural crest cell migration. | Coles, E., et al. 2004. Development. 131: 5309-17. PMID: 15456729
- Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing. | O'Connor, MB., et al. 2006. Development. 133: 183-93. PMID: 16368928
- Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation. | Rentzsch, F., et al. 2006. Development. 133: 801-11. PMID: 16439480
- Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. | Ikeya, M., et al. 2006. Development. 133: 4463-73. PMID: 17035289
- Bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4. | Jasuja, R., et al. 2007. J Biol Chem. 282: 9053-62. PMID: 17255107
- Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells. | Koike, N., et al. 2007. J Biol Chem. 282: 15843-50. PMID: 17400546
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Crossveinless-2 Antibody (G-8) | sc-377502 | 200 µg/ml | $322.00 | |||
Crossveinless-2 Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-530031 | 200 µg Ab; 10 µg BP | $361.00 | |||
Crossveinless-2 Antibody (G-8): m-IgGκ BP-HRP Bundle | sc-523347 | 200 µg Ab, 40 µg BP | $361.00 | |||
Crossveinless-2 Antibody (G-8) AC | sc-377502 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Crossveinless-2 Antibody (G-8) HRP | sc-377502 HRP | 200 µg/ml | $322.00 | |||
Crossveinless-2 Antibody (G-8) FITC | sc-377502 FITC | 200 µg/ml | $336.00 | |||
Crossveinless-2 Antibody (G-8) PE | sc-377502 PE | 200 µg/ml | $349.00 | |||
Crossveinless-2 Antibody (G-8) Alexa Fluor® 488 | sc-377502 AF488 | 200 µg/ml | $364.00 | |||
Crossveinless-2 Antibody (G-8) Alexa Fluor® 546 | sc-377502 AF546 | 200 µg/ml | $364.00 | |||
Crossveinless-2 Antibody (G-8) Alexa Fluor® 594 | sc-377502 AF594 | 200 µg/ml | $364.00 | |||
Crossveinless-2 Antibody (G-8) Alexa Fluor® 647 | sc-377502 AF647 | 200 µg/ml | $364.00 | |||
Crossveinless-2 Antibody (G-8) Alexa Fluor® 680 | sc-377502 AF680 | 200 µg/ml | $364.00 | |||
Crossveinless-2 Antibody (G-8) Alexa Fluor® 790 | sc-377502 AF790 | 200 µg/ml | $364.00 |