CRISP-3 Antibody (D-6): sc-377505
- CRISP-3 Antibody (D-6) is a mouse monoclonal IgG2a κ CRISP-3 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 21-99 mapping near the N-terminus of CRISP-3 of mouse origin
- CRISP-3 Antibody (D-6) is recommended for detection of CRISP-3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CRISP-3 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CRISP-3 Antibody (D-6) for WB and IHC(P) applications. These reagents are now offered in bundles with CRISP-3 Antibody (D-6) (see ordering information below).
CRISP-3 Antibody (D-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects CRISP-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CRISP-3 (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cysteine-rich secretory proteins (CRISPs) are a family of evolutionarily conserved proteins that play significant roles in the innate immune system and are transcriptionally regulated by androgens in various tissues. CRISP-3 is primarily expressed in the pancreas and prostate, as well as in saliva, indicating potential involvement in reproductive and digestive processes. Notably, CRISP-3 is an early response gene that may contribute to the pathophysiology of autoimmune conditions such as Sjogren′s syndrome, highlighting importance in immune regulation. Additionally, CRISP-3 interacts with other proteins involved in sperm-egg fusion, which is crucial for successful fertilization. Anti-CRISP-3 antibody (D-6) in multiple formats serves as a versatile tool for researchers studying functional implications of CRISP-3 in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRISP-3 Antibody (D-6) References:
- Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. | Liao, Q., et al. 2003. Histol Histopathol. 18: 425-33. PMID: 12647793
- Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. | Udby, L., et al. 2004. Biochemistry. 43: 12877-86. PMID: 15461460
- Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract. | Udby, L., et al. 2005. J Androl. 26: 333-42. PMID: 15867000
- beta-Microseminoprotein binds CRISP-3 in human seminal plasma. | Udby, L., et al. 2005. Biochem Biophys Res Commun. 333: 555-61. PMID: 15950934
- Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland. | Bjartell, A., et al. 2006. Prostate. 66: 591-603. PMID: 16388501
- Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. | Bjartell, AS., et al. 2007. Clin Cancer Res. 13: 4130-8. PMID: 17634540
- Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjögren's syndrome. | Laine, M., et al. 2007. Arthritis Rheum. 56: 2575-84. PMID: 17665393
- A model of the complex between human beta-microseminoprotein and CRISP-3 based on NMR data. | Ghasriani, H., et al. 2009. Biochem Biophys Res Commun. 378: 235-9. PMID: 19026612
- The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. | Krätzschmar, J., et al. 1996. Eur J Biochem. 236: 827-36. PMID: 8665901
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRISP-3 Antibody (D-6) | sc-377505 | 200 µg/ml | $322.00 | |||
CRISP-3 Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-530032 | 200 µg Ab; 10 µg BP | $361.00 | |||
CRISP-3 Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-523349 | 200 µg Ab, 40 µg BP | $361.00 | |||
CRISP-3 Antibody (D-6): m-IgG2a BP-HRP Bundle | sc-547421 | 200 µg Ab; 10 µg BP | $361.00 | |||
CRISP-3 Antibody (D-6) AC | sc-377505 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CRISP-3 Antibody (D-6) HRP | sc-377505 HRP | 200 µg/ml | $322.00 | |||
CRISP-3 Antibody (D-6) FITC | sc-377505 FITC | 200 µg/ml | $336.00 | |||
CRISP-3 Antibody (D-6) PE | sc-377505 PE | 200 µg/ml | $349.00 | |||
CRISP-3 Antibody (D-6) Alexa Fluor® 488 | sc-377505 AF488 | 200 µg/ml | $364.00 | |||
CRISP-3 Antibody (D-6) Alexa Fluor® 546 | sc-377505 AF546 | 200 µg/ml | $364.00 | |||
CRISP-3 Antibody (D-6) Alexa Fluor® 594 | sc-377505 AF594 | 200 µg/ml | $364.00 | |||
CRISP-3 Antibody (D-6) Alexa Fluor® 647 | sc-377505 AF647 | 200 µg/ml | $364.00 | |||
CRISP-3 Antibody (D-6) Alexa Fluor® 680 | sc-377505 AF680 | 200 µg/ml | $364.00 | |||
CRISP-3 Antibody (D-6) Alexa Fluor® 790 | sc-377505 AF790 | 200 µg/ml | $364.00 |