CRISP-2 Antibody (E-12): sc-377391

CRISP-2 Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects CRISP-2 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRISP-2, also known as testis-specific protein TPX1 or cancer/testis antigen 36 (CT36), is a 243 amino acid secreted protein predominantly expressed in the testis and epididymis, where CRISP-2 plays a crucial role in sperm maturation and function. CRISP-2 is believed to be involved in calcium fluxes during sperm capacitation, a process essential for sperm to acquire the ability to fertilize an egg, by regulating the activity of specific ion channels. Proper functioning of CRISP-2 is vital for male fertility, and dysregulation may contribute to reproductive disorders. Additionally, CRISP-2 has been implicated in various physiological processes, making CRISP-2 a significant target for research in reproductive biology and potential therapeutic interventions. anti-CRISP-2 antibody (E-12) provides reliable detection and characterization of CRISP-2, serving as an invaluable tool for researchers studying male reproductive health and related conditions.

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CRISP-2 Antibody (E-12) References:

1. Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction.  |  Busso, D., et al. 2005. Mol Hum Reprod. 11: 299-305. PMID: 15734896
2. Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm.  |  Gibbs, GM., et al. 2007. Biol Reprod. 77: 108-14. PMID: 17377140
3. Cysteine rich secretory proteins in reproduction and venom.  |  Gibbs, GM. and O'Bryan, MK. 2007. Soc Reprod Fertil Suppl. 65: 261-7. PMID: 17644967
4. Molecular mechanisms involved in gamete interaction: evidence for the participation of cysteine-rich secretory proteins (CRISP) in sperm-egg fusion.  |  Da Ros, V., et al. 2007. Soc Reprod Fertil Suppl. 65: 353-6. PMID: 17644975
5. Increased level of antibodies cross-reacting with Ves v 5 and CRISP-2 in MAR-positive patients.  |  Brunner-Agten, S., et al. 2013. Int Arch Allergy Immunol. 160: 47-55. PMID: 22948171
6. Mapping of the binding sites involved in PSP94-CRISP-3 interaction by molecular dissection of the complex.  |  Breed, AA., et al. 2013. Biochim Biophys Acta. 1830: 3019-29. PMID: 23375721
7. Isolation and characterization of the androgen-dependent mouse cysteine-rich secretory protein-3 (CRISP-3) gene.  |  Schwidetzky, U., et al. 1995. Biochem J. 309 (Pt 3): 831-6. PMID: 7639699
8. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3.  |  Krätzschmar, J., et al. 1996. Eur J Biochem. 236: 827-36. PMID: 8665901
9. Differential androgen regulation of the murine genes for cysteine-rich secretory proteins (CRISP).  |  Haendler, B., et al. 1997. Eur J Biochem. 250: 440-6. PMID: 9428696
10. Expression of transcripts for cysteine-rich secretory proteins (CRISPs) in the murine lacrimal gland.  |  Haendler, B., et al. 1999. J Cell Physiol. 178: 371-8. PMID: 9989783

The preferred CRISP-2 antibody is CRISP-2 Antibody (D-10): sc-390914.