CRIK Antibody (6): sc-136283
- CRIK Antibody (6) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1420-1612 of CRIK of rat origin
- recommended for detection of CRIK of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CRIK Antibody (6). This work is in progress.
QUICK LINKS
SEE ALSO...
CRIK Antibody (6) is a mouse monoclonal IgG1 antibody that detects CRIK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CRIK, or Citron Rho-interacting kinase, is a vital 2,027 amino acid cytoplasmic protein that plays a crucial role in the regulation of cytokinesis and the development of the central nervous system. CRIK is characterized by its complex structure, which includes an AGC-kinase C-terminal domain, a CNH domain, a PH domain, a phorbol-ester/DAG-type zinc finger, and a protein kinase domain, all of which contribute to functional versatility. The structural integrity of CRIK is essential for interaction with other proteins, such as KIF14, which is necessary for the proper localization of KIF14 to the central spindle and midbody during cell division. The presence of multiple alternatively spliced isoforms of CRIK, encoded by a gene located on chromosome 12q24.23, further highlights CRIK′s adaptability and importance in various cellular processes. Anti-CRIK antibody (6) is an invaluable tool for researchers studying the dynamics of the cytoskeleton and the mechanisms underlying cell division and neurodevelopment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRIK Antibody (6) References:
- Proteomic analysis of mantle-cell lymphoma by protein microarray. | Ghobrial, IM., et al. 2005. Blood. 105: 3722-30. PMID: 15650054
- Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression. | Grossi, M., et al. 2005. Proc Natl Acad Sci U S A. 102: 11313-8. PMID: 16061799
- Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction. | Seo, J., et al. 2016. Free Radic Biol Med. 90: 133-44. PMID: 26593676
- E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. | Swartz, KL., et al. 2017. Mol Cell Biol. 37: PMID: 27795297
- Transcriptomic analysis of gene expression profiles of stomach carcinoma reveal abnormal expression of mitotic components. | Tong, H., et al. 2017. Life Sci. 170: 41-49. PMID: 27923621
- Mutations of KIF14 cause primary microcephaly by impairing cytokinesis. | Moawia, A., et al. 2017. Ann Neurol. 82: 562-577. PMID: 28892560
- Biallelic variants in KIF14 cause intellectual disability with microcephaly. | Makrythanasis, P., et al. 2018. Eur J Hum Genet. 26: 330-339. PMID: 29343805
- Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. | Sahin, I., et al. 2019. Blood Adv. 3: 995-1002. PMID: 30940634
- Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells. | Martino, J., et al. 2023. Elife. 12: PMID: 37073955
- Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. | Di Cunto, F., et al. 1998. J Biol Chem. 273: 29706-11. PMID: 9792683
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRIK Antibody (6) | sc-136283 | 50 µg/0.5 ml | $322.00 |