CRIK Activators
The CRIK activators represent a distinctive class of chemicals meticulously chosen to modulate the activity of the Cdc42/Rac interactive binding (CRIK) protein. These compounds exert their effects by precisely targeting key signaling pathways and cellular processes, orchestrating a sophisticated network that ultimately culminates in the activation of CRIK. One prominent member of this chemical class is Nordihydroguaiaretic acid (NDGA), which activates CRIK by inhibiting the c-Jun N-terminal kinase (JNK) signaling pathway. NDGA specifically targets the upstream kinases of JNK, preventing its activation and resulting in enhanced CRIK activity. This mechanism underscores the intricate connection between stress-activated signaling pathways and the regulation of CRIK, providing a nuanced understanding of the molecular events governing its activation.
Another noteworthy compound is Cerulenin, which activates CRIK by modulating the fatty acid synthesis pathway. By inhibiting fatty acid synthase (FAS), Cerulenin induces alterations in cellular lipid metabolism, leading to the subsequent activation of CRIK. This highlights the integration of metabolic pathways in the regulation of CRIK, showcasing the multifaceted nature of its activation. These CRIK activators collectively exemplify the targeted manipulation of cellular pathways to influence the activity of CRIK. Understanding the specific biochemical and cellular mechanisms impacted by each compound provides valuable insights into the molecular intricacies governing CRIK activation. This detailed knowledge opens avenues for targeted interventions in cellular processes and potential applications in research and biotechnology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
NDGA activates CRIK by inhibiting the JNK signaling pathway. It specifically targets the upstream kinases of JNK, preventing its activation and leading to the enhanced activation of CRIK. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 activates CRIK by inhibiting the JNK signaling pathway. It directly targets JNK, preventing its phosphorylation and activation, which results in increased activation of CRIK. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates CRIK by inducing stress-activated protein kinase (SAPK)/JNK signaling. It promotes the phosphorylation and activation of JNK, leading to the subsequent activation of CRIK. | ||||||
JNK Inhibitor VIII | 894804-07-0 | sc-202673 | 5 mg | $272.00 | 2 | |
JNK Inhibitor VIII activates CRIK by inhibiting the JNK signaling pathway. It specifically targets JNK, preventing its activation and leading to increased activation of CRIK. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin activates CRIK by modulating the fatty acid synthesis pathway. It inhibits fatty acid synthase (FAS), leading to alterations in cellular lipid metabolism and subsequent activation of CRIK. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates CRIK by influencing AMP-activated protein kinase (AMPK) signaling. It activates AMPK, leading to downstream effects on cellular energy metabolism and the subsequent activation of CRIK. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 activates CRIK by activating AMP-activated protein kinase (AMPK). It serves as an AMP mimetic, promoting AMPK phosphorylation and subsequent activation, which indirectly enhances CRIK activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 activates CRIK by modulating calcium signaling. It induces intracellular calcium release, leading to the activation of calcium-dependent signaling pathways and subsequent activation of CRIK. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 activates CRIK by inhibiting p38 MAPK signaling. It specifically targets p38 MAPK, preventing its activation and leading to the enhanced activation of CRIK. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin activates CRIK by inhibiting phosphoinositide 3-kinase (PI3K) signaling. It blocks PI3K activity, leading to downstream effects on cellular processes and the subsequent activation of CRIK. | ||||||