CRELD2 Antibody (A-8): sc-365168
- CRELD2 Antibody (A-8) is a mouse monoclonal IgG1 κ CRELD2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 141-173 within an internal region of CRELD2 of human origin
- CRELD2 Antibody (A-8) is recommended for detection of CRELD2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- Anti-CRELD2 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for CRELD2 Antibody (A-8) for WB applications. This reagent is now offered in a bundle with CRELD2 Antibody (A-8) (see ordering information below).
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CRELD2 Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CRELD2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRELD2 (A-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. CRELD2, known as cysteine-rich with EGF-like domains 2, is a 353 amino acid protein that plays a crucial role in cellular processes, including cell adhesion and development, due to its structure, which features two fibronectin type III-like domains and two EGF-like domains. These structural elements are essential for CRELD2′s function, as they facilitate interactions with other proteins and contribute to CRELD2′s stability and localization within the endoplasmic reticulum, where CRELD2 is synthesized and subsequently secreted. CRELD2 has been shown to interact with the acetylcholine receptor subunit AChRα4, potentially influencing transport and function, which is vital for neuromuscular signaling. Notably, human CRELD2 shares 69% amino acid identity with mouse CRELD2, indicating a conserved role across species, and multiple isoforms arise from alternative splicing, adding complexity to CRELD2′s functional repertoire. The gene encoding CRELD2 is located on human chromosome 22, a region associated with various genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2, highlighting the importance of studying CRELD2 in the context of human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRELD2 Antibody (A-8) References:
- Disease genes and chromosomes: disease maps of the human genome. Chromosome 22. | Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
- Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. | Rupp, PA., et al. 2002. Gene. 293: 47-57. PMID: 12137942
- The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. | Ortiz, JA., et al. 2005. J Neurochem. 95: 1585-96. PMID: 16238698
- CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. | Maslen, CL., et al. 2006. Gene. 382: 111-20. PMID: 16919896
- Identification of novel androgen receptor target genes in prostate cancer. | Jariwala, U., et al. 2007. Mol Cancer. 6: 39. PMID: 17553165
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRELD2 Antibody (A-8) | sc-365168 | 200 µg/ml | $322.00 | |||
CRELD2 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-525862 | 200 µg Ab; 10 µg BP | $361.00 | |||
CRELD2 Antibody (A-8) AC | sc-365168 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CRELD2 Antibody (A-8) HRP | sc-365168 HRP | 200 µg/ml | $322.00 | |||
CRELD2 Antibody (A-8) FITC | sc-365168 FITC | 200 µg/ml | $336.00 | |||
CRELD2 Antibody (A-8) PE | sc-365168 PE | 200 µg/ml | $349.00 | |||
CRELD2 Antibody (A-8) Alexa Fluor® 488 | sc-365168 AF488 | 200 µg/ml | $364.00 | |||
CRELD2 Antibody (A-8) Alexa Fluor® 546 | sc-365168 AF546 | 200 µg/ml | $364.00 | |||
CRELD2 Antibody (A-8) Alexa Fluor® 594 | sc-365168 AF594 | 200 µg/ml | $364.00 | |||
CRELD2 Antibody (A-8) Alexa Fluor® 647 | sc-365168 AF647 | 200 µg/ml | $364.00 | |||
CRELD2 Antibody (A-8) Alexa Fluor® 680 | sc-365168 AF680 | 200 µg/ml | $364.00 | |||
CRELD2 Antibody (A-8) Alexa Fluor® 790 | sc-365168 AF790 | 200 µg/ml | $364.00 | |||
CRELD2 (A-8) Neutralizing Peptide | sc-365168 P | 100 µg/0.5 ml | $69.00 |