CREB1 Antibody (24H4B): sc-271
- CREB1 Antibody (24H4B) is a mouse monoclonal IgG2b κ, cited in 105 publications, provided at 200 µg/ml
- raised against amino acids 254-327 mapping within the DNA binding and dimerization domain of CREB-1 of human origin
- Anti-CREB1 Antibody (24H4B) is recommended for detection of CREB-1A and CREB-1B of mouse, rat and human origin by WB, IP and IF
- Anti-CREB1 Antibody (24H4B) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-271 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CREB1 Antibody (24H4B). This work is in progress.
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CREB-1 Antibody (24H4B) is a mouse monoclonal IgG2b kappa light chain antibody engineered against amino acids 254-327 within the DNA binding and dimerization domain of human CREB-1, also called CREB and CREB1, enabling robust detection of CREB-1A and CREB-1B isoforms across mouse, rat, and human species through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. CREB-1 (cAMP response element-binding protein 1) is a crucial transcription factor that regulates gene expression by binding to the cAMP response element (CRE) in the promoters of target genes, thereby modulating essential cellular processes such as metabolism, neuronal plasticity, and survival. Upon phosphorylation at Serine 133 by protein kinase A, CREB-1 undergoes a conformational change that facilitates interaction with the CREB-binding protein (CBP), promoting the assembly of the basal transcription complex and activating transcriptional programs critical for cellular responses to hormonal and stress signals. This regulatory mechanism underscores CREB-1′s pivotal role in neoglucogenesis through interaction with the nuclear coactivator PGC-1, as well as involvement in the pathogenesis of type II diabetes and dilated cardiomyopathy, highlighting significance in both metabolic regulation and cardiovascular health. Available in non-conjugated form and various conjugated forms including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CREB1 Antibody (24H4B) | sc-271 | 200 µg/ml | $322.00 | |||
CREB1 Antibody (24H4B) X | sc-271 X | 200 µg/0.1 ml | $322.00 | |||
CREB1 Antibody (24H4B) AC | sc-271 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CREB1 Antibody (24H4B) HRP | sc-271 HRP | 200 µg/ml | $322.00 | |||
CREB1 Antibody (24H4B) FITC | sc-271 FITC | 200 µg/ml | $336.00 | |||
CREB1 Antibody (24H4B) PE | sc-271 PE | 200 µg/ml | $349.00 | |||
CREB1 Antibody (24H4B) Alexa Fluor® 488 | sc-271 AF488 | 200 µg/ml | $364.00 | |||
CREB1 Antibody (24H4B) Alexa Fluor® 546 | sc-271 AF546 | 200 µg/ml | $364.00 | |||
CREB1 Antibody (24H4B) Alexa Fluor® 594 | sc-271 AF594 | 200 µg/ml | $364.00 | |||
CREB1 Antibody (24H4B) Alexa Fluor® 647 | sc-271 AF647 | 200 µg/ml | $364.00 | |||
CREB1 Antibody (24H4B) Alexa Fluor® 680 | sc-271 AF680 | 200 µg/ml | $364.00 | |||
CREB1 Antibody (24H4B) Alexa Fluor® 790 | sc-271 AF790 | 200 µg/ml | $364.00 |