creatine kinase-M/B Antibody (CK1): sc-56896

Creatine kinase-M/B Antibody (CK1) is a mouse monoclonal IgG1 antibody that detects creatine kinase-M/B in human samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Creatine kinase-M/B plays a crucial role in cellular energy metabolism, particularly in muscle and brain tissues, where creatine kinase-M/B facilitates rapid regeneration of adenosine triphosphate (ATP) from creatine phosphate during periods of high energy demand. This function is vital for maintaining energy homeostasis, especially in tissues that experience fluctuating energy requirements, such as during muscle contraction or neuronal activity. Creatine kinase-M/B isoform is specifically expressed in muscle and brain, highlighting creatine kinase-M/B importance in these tissues′ metabolic processes. Additionally, creatine kinase-M/B is involved in calcium homeostasis regulation, which is essential for muscle contraction and neurotransmitter release in neurons. By providing localized ATP, creatine kinase-M/B ensures energy is readily available at critical sites, thereby supporting normal physiological functions of muscle and brain cells. Anti-creatine kinase-M/B antibody (CK1) is an invaluable tool for researchers studying energy metabolism and related disorders, offering insights into ATP production and utilization dynamics in human tissues.

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creatine kinase-M/B Antibody (CK1) References:

1. Determination of creatine kinase isoenzyme MB activity in serum using immunological inhibition of creatine kinase M subunit activity. Activity kinetics and diagnostic significance in myocardial infarction.  |  Neumeier, D., et al. 1976. Clin Chim Acta. 73: 445-51. PMID: 1000863
2. Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter.  |  Steen, C., et al. 2010. PLoS One. 5: e10811. PMID: 20520825
3. Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.  |  Dimitrijevic, A., et al. 2014. PLoS One. 9: e100622. PMID: 24955845
4. Human creatine kinase: isolation and sequence analysis of cDNA clones for the B subunit, development of subunit specific probes and determination of gene copy number.  |  Villarreal-Levy, G., et al. 1987. Biochem Biophys Res Commun. 144: 1116-27. PMID: 3034271
5. Structure and expression of the human creatine kinase B gene.  |  Mariman, EC., et al. 1987. Genomics. 1: 126-37. PMID: 3692484
6. Radioimmunoassay of creatine kinase B-isoenzymes in serum of patients with azotemia, obstructive uropathy, or carcinoma of the prostate or bladder.  |  Homburger, HA., et al. 1980. Clin Chem. 26: 1821-4. PMID: 6159995
7. Serum creatine kinase B concentrations in acute cerebrovascular diseases.  |  Pfeiffer, FE., et al. 1984. Arch Neurol. 41: 1175-8. PMID: 6487101
8. Creatine kinase and creatine kinase B-subunit activity in serum in cases of suspected myocardial infarction.  |  Gerhardt, W., et al. 1982. Clin Chem. 28: 277-83. PMID: 7055948
9. Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle.  |  Vincent, CK., et al. 1993. Mol Cell Biol. 13: 1264-72. PMID: 8423791
10. Biochemical markers of early and late spermatogenesis: relationship between the lactate dehydrogenase-X and creatine kinase-M isoform concentrations in human spermatozoa.  |  Lalwani, S., et al. 1996. Mol Reprod Dev. 43: 495-502. PMID: 9052941

The preferred creatine kinase-B antibody is creatine kinase-B Antibody (B-9): sc-373686.