creatine kinase-M/B Antibody (BDI937): sc-56895
- creatine kinase-M/B Antibody (BDI937) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against creatine kinase-M/B dimer dimer of human origin
- recommended for detection of creatine kinase-M/B of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for creatine kinase-M/B Antibody (BDI937). This work is in progress.
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Creatine kinase-M/B Antibody (BDI937) is a mouse monoclonal IgG1 antibody that detects creatine kinase-M/B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Creatine kinase-M/B plays a crucial role in cellular energy metabolism, particularly in muscle and brain tissues, where creatine kinase-M/B facilitates the transfer of phosphate groups to regenerate adenosine triphosphate (ATP) from creatine phosphate. This process is vital for maintaining energy homeostasis, especially during periods of high energy demand, such as muscle contraction and neuronal activity. Creatine kinase-M/B is predominantly located in the cytoplasm of muscle and brain cells, where creatine kinase-M/B ensures a rapid supply of ATP, thereby supporting essential functions like muscle contraction and neurotransmission. Additionally, creatine kinase-M/B is involved in the regulation of calcium homeostasis, which is critical for muscle function and signal transduction in neurons. Anti-creatine kinase-M/B antibody (BDI937) enables researchers to gain insights into the energy dynamics of cells and investigate the role of this enzyme in various physiological and pathological conditions, including muscle disorders and neurodegenerative diseases.
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creatine kinase-M/B Antibody (BDI937) References:
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- Creatine kinase B is a target molecule of reactive oxygen species in cervical cancer. | Choi, H., et al. 2001. Mol Cells. 12: 412-7. PMID: 11804344
- Regulation of T cell development and activation by creatine kinase B. | Zhang, Y., et al. 2009. PLoS One. 4: e5000. PMID: 19337362
- Spermatogenesis-related change in the synthesis of the creatine kinase B-type and M-type isoforms in human spermatozoa. | Huszar, G. and Vigue, L. 1990. Mol Reprod Dev. 25: 258-62. PMID: 2331374
- Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci. | Kaye, FJ., et al. 1987. J Clin Invest. 79: 1412-20. PMID: 2883200
- Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71. | Sandebring-Matton, A., et al. 2021. Front Aging Neurosci. 13: 735334. PMID: 34867272
- Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation. | Renzi, G., et al. 2025. Mol Metab. 92: 102082. PMID: 39675471
- Creatine kinase B-subunit activity in serum after immunoinhibition of M-subunit activity. | Gerhardt, W. and Waldenström, J. 1979. Clin Chem. 25: 1274-80. PMID: 455648
- Identification and localization of creatine kinase B and M in normal, ischemic and necrotic myocardium. An immunohistochemical study. | Siegel, RJ., et al. 1984. J Mol Cell Cardiol. 16: 95-103. PMID: 6366242
- Activation of creatine kinase-B and phospholamban gene expression in transformed latissimus dorsi muscle: evaluation of mRNA by polymerase chain reaction. | Alam, M., et al. 1996. J Mol Cell Cardiol. 28: 1901-10. PMID: 8899549
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
creatine kinase-M/B Antibody (BDI937) | sc-56895 | 100 µg/ml | $316.00 |