creatine kinase-M/B Antibody (1.BB.105): sc-70881

Creatine kinase-M/B Antibody (1.BB.105) is a mouse monoclonal IgG1 kappa light chain antibody that detects creatine kinase-M/B of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-creatine kinase-M/B antibody (1.BB.105) is available in a non-conjugated form, specifically designed for researchers studying energy metabolism dynamics in human tissues. Creatine kinases catalyze the reversible phosphate transfer from creatine to adenosine diphosphate (ADP), regenerating adenosine triphosphate (ATP) in high energy demand areas. This function maintains cellular activities in muscle and brain tissues where rapid ATP turnover is essential. Creatine kinase-M/B (1.BB.105) monoclonal antibody targets an isoform involved in ATP regulation in both muscle and brain tissues, highlighting significance in ischemia and muscle disorders. The creatine kinase-M/B structure includes distinct regions for substrate binding and catalysis, essential for enzymatic activity and interaction with other energy metabolism proteins. Research on creatine kinase-M/B and associated interactions provides valuable insights into metabolic disorders and potential therapeutic approaches.

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creatine kinase-M/B Antibody (1.BB.105) References:

1. Clinical applications of microarray technology: creatine kinase B is an up-regulated gene in epithelial ovarian cancer and shows promise as a serum marker.  |  Huddleston, HG., et al. 2005. Gynecol Oncol. 96: 77-83. PMID: 15589584
2. Serum creatine kinase B subunit in patients with renal cell carcinoma.  |  Takashi, M., et al. 1992. Urol Int. 48: 144-8. PMID: 1585508
3. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.  |  Debrincat, MA., et al. 2007. J Biol Chem. 282: 4728-4737. PMID: 17148442
4. Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein.  |  Hara, H., et al. 2009. J Virol. 83: 5137-47. PMID: 19264780
5. cDNA cloning and mapping of the human creatine kinase M gene to 19q13.  |  Nigro, JM., et al. 1987. Am J Hum Genet. 40: 115-25. PMID: 3031982
6. Myoglobin concentration, creatine kinase activity, and creatine kinase B subunit concentrations in serum during thyroid disease.  |  Docherty, I., et al. 1984. Clin Chem. 30: 42-5. PMID: 6690150
7. Creatine kinase-MB mass concentration versus creatine kinase-B activity for the detection of acute myocardial infarction in patients with slightly elevated total creatine kinase activity in serum.  |  Hulting, J., et al. 1994. J Intern Med. 235: 211-6. PMID: 8120516
8. Changes in creatine kinase M localization in acute ischemic myocardial cells. Immunoelectron microscopic studies.  |  Otsu, N., et al. 1993. Circ Res. 73: 935-42. PMID: 8403263
9. In situ hybridization for creatine kinase-B messenger RNA in rat uterus and brain.  |  Bergen, HT., et al. 1993. Mol Cell Endocrinol. 92: 111-9. PMID: 8472861
10. Selective induction of the creatine kinase-B gene in chronic volume overload hypertrophy is not affected by ACE-inhibitor therapy.  |  Schultz, D., et al. 1997. J Mol Cell Cardiol. 29: 2665-73. PMID: 9344761

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-creatine kinase-M/B Antibody (1.BB.105) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-creatine kinase-M/B Antibody (1.BB.105) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

creatine kinase-M/B Antibody (1.BB.105) Specifications

Alternate Product Name: creatine kinase-M/B

Product Clone Name: 1.BB.105

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: creatine kinase-M/B dimer

Epitope Species: human

Product Reactivity/Detection: creatine kinase-M/B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for creatine kinase-M/B Antibody (1.BB.105): N/A

The preferred creatine kinase-B antibody is creatine kinase-B Antibody (B-9): sc-373686.