creatine kinase-M Antibody (MM-64): sc-69878
- creatine kinase-M Antibody (MM-64) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against creatine kinase-M of human origin
- recommended for detection of creatine kinase-M of mouse, rat and human origin by WB and IP
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for creatine kinase-M Antibody (MM-64) for WB applications. This reagent is now offered in a bundle with creatine kinase-M Antibody (MM-64) (see ordering information below).
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Creatine kinase-M Antibody (MM-64) is a mouse monoclonal IgG1 antibody that detects creatine kinase-M in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Creatine kinase-M plays a crucial role in energy metabolism, particularly in muscle tissue, where creatine kinase-M facilitates the rapid regeneration of adenosine triphosphate (ATP) during periods of high energy demand, such as during muscle contraction. This isoform, consisting of 381 amino acids, is specifically expressed in skeletal muscle and is vital for maintaining energy homeostasis, especially in fast-twitch muscle fibers that require quick bursts of energy. The proper functioning of creatine kinase-M is essential not only for muscle performance but also for overall metabolic health, as disruptions in creatine kinase-M activity can lead to muscle fatigue and impaired recovery. Anti-creatine kinase-M antibody (MM-64) is an invaluable tool for researchers studying muscle physiology, energy metabolism, and related pathologies, providing insights into the intricate mechanisms that govern cellular energy dynamics.
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creatine kinase-M Antibody (MM-64) References:
- Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance. | Buscemi, N., et al. 2003. Mol Cell Biochem. 251: 145-51. PMID: 14575316
- Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors. | van Deursen, J. and Wieringa, B. 1992. Nucleic Acids Res. 20: 3815-20. PMID: 1508665
- CK-MM autoantibodies: prevalence, immune complexes, and effect on CK clearance. | Warren, GL., et al. 2006. Muscle Nerve. 34: 335-46. PMID: 16810680
- CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise. | Heled, Y., et al. 2007. J Appl Physiol (1985). 103: 504-10. PMID: 17478608
- CK-MM gene polymorphism does not influence the blood CK activity levels after exhaustive eccentric exercise. | Yamin, C., et al. 2010. Int J Sports Med. 31: 213-7. PMID: 20157874
- Modulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells. | van Deursen, J., et al. 1991. Nucleic Acids Res. 19: 2637-43. PMID: 2041741
- Accumulation of CK-MM is impaired in innervated and contracting cultured muscle fibers of Duchenne muscular dystrophy patients. | Askanas, V., et al. 1987. Life Sci. 41: 927-33. PMID: 3613854
- Enzymatic method for quantitating creatine kinase M and B isoenzyme composition in cardiac tissue: consideration for utilization in studies of developing and adult rat heart. | Dowell, RT. and Fu, MC. 1995. Methods Find Exp Clin Pharmacol. 17: 29-37. PMID: 7623518
- Simultaneous automated measurement of serum total CK and CK-MM isoform ratio in serum. | Uji, Y., et al. 1994. J Clin Lab Anal. 8: 273-6. PMID: 7807281
- Physicochemical studies on the creatine kinase M-line protein and its interaction with myosin and myosin fragments. | Mani, RS. and Kay, CM. 1976. Biochim Biophys Acta. 453: 391-9. PMID: 793621
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
creatine kinase-M Antibody (MM-64) | sc-69878 | 200 µg/ml | $316.00 | |||
creatine kinase-M Antibody (MM-64): m-IgG Fc BP-HRP Bundle | sc-539254 | 200 µg Ab; 10 µg BP | $354.00 |