creatine kinase-M Antibody (MM-25): sc-69877

Creatine kinase-M Antibody (MM-25) is a mouse monoclonal IgG1 antibody that detects creatine kinase-M in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Creatine kinase-M is a muscle tissue-specific isoform of creatine kinase, consisting of 381 amino acids, and plays a crucial role in energy metabolism by catalyzing the transfer of phosphate from creatine to adenosine diphosphate (ADP), thereby regenerating adenosine triphosphate (ATP) during periods of high energy demand. This function is particularly important in muscle cells, where ATP is essential for muscle contraction and overall cellular function. The regulation of ATP levels by creatine kinase-M is vital for maintaining energy homeostasis, especially during intense physical activity or stress. Additionally, creatine kinase-M is involved in the energetic regulation of calcium pumps, which are critical for muscle relaxation and contraction, highlighting its significance in both muscle physiology and pathophysiology. Anti-creatine kinase-M antibody (MM-25) is an invaluable tool for researchers studying muscle metabolism, energy regulation, and related disorders, providing insights into the underlying mechanisms of muscle function and disease.

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creatine kinase-M Antibody (MM-25) References:

1. Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors.  |  van Deursen, J. and Wieringa, B. 1992. Nucleic Acids Res. 20: 3815-20. PMID: 1508665
2. Effect of varicocelectomy on sperm creatine kinase, HspA2 chaperone protein (creatine kinase-M type), LDH, LDH-X, and lipid peroxidation product levels in infertile men with varicocele.  |  Yeşilli, C., et al. 2005. Urology. 66: 610-5. PMID: 16140088
3. CK-MM Polymorphism is Associated With Physical Fitness Test Scores in Military Recruits.  |  Sprouse, C., et al. 2015. Mil Med. 180: 1001-5. PMID: 26327553
4. Diagnostic use of CK-MM and CK-MB isoforms for detecting myocardial infarction.  |  Apple, FS. 1989. Clin Lab Med. 9: 643-54. PMID: 2686906
5. Immunocytochemical localization of creatine kinase M in canine myocardial cells: most creatine kinase M is distributed in the A-band.  |  Otsu, N., et al. 1989. J Histochem Cytochem. 37: 1465-70. PMID: 2778305
6. Polygenic study of endurance-associated genetic markers ACE I/D, ACTN3 Arg(R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T) in male Gorkha soldiers.  |  Malhotra, S., et al. 2017. Sports Med Open. 3: 17. PMID: 28444615
7. Assessment of serum CK-MM level as a bioindicator for work-related musculoskeletal injuries among Emergency hospital workers.  |  Shehata, RS., et al. 2022. Toxicol Ind Health. 38: 11-18. PMID: 35100895
8. Evaluation of the GSP Creatine Kinase-MM Assay and Assessment of CK-MM Stability in Newborn, Patient, and Contrived Dried Blood Spots for Newborn Screening for Duchenne Muscular Dystrophy.  |  Migliore, BA., et al. 2022. Int J Neonatal Screen. 8: PMID: 35225934
9. Elevated serum creatine kinase (CK-MM) in petrol sniffers using leaded or unleaded fuel.  |  Burns, CB., et al. 1994. J Toxicol Clin Toxicol. 32: 527-39. PMID: 7932912
10. Cloning, characterization, and expression in Escherichia coli of three creatine kinase muscle isoenzyme cDNAs from carp (Cyprinus carpio) striated muscle.  |  Sun, HW., et al. 1998. J Biol Chem. 273: 33774-80. PMID: 9837966

The preferred creatine kinase-M antibody is creatine kinase-M Antibody (G-9): sc-365046.