creatine kinase-M Antibody (MM): sc-69860

Creatine kinase-M Antibody (MM) is a mouse monoclonal IgG1 antibody that detects creatine kinase-M in mouse, rat, and human samples through western blotting (WB). Creatine kinase-M, also known as CK-M, is a muscle tissue-specific isoform of creatine kinase that plays a crucial role in energy metabolism by catalyzing the transfer of phosphate from creatine to adenosine diphosphate (ADP), thereby regenerating adenosine triphosphate (ATP) during periods of high energy demand. This function is particularly important in muscle cells, where ATP is essential for muscle contraction and overall cellular function. The regulation of ATP levels by creatine kinase-M is vital for maintaining energy homeostasis, especially during intense physical activity or stress. Additionally, creatine kinase-M is localized in the cytoplasm of muscle cells, which allows for rapid access to ATP when needed, highlighting its significance in muscle physiology and pathophysiology. Anti-creatine kinase-M antibody (MM) is an invaluable tool for researchers studying muscle metabolism, energy regulation, and related disorders, providing insights into the underlying mechanisms of muscle function and disease.

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creatine kinase-M Antibody (MM) References:

1. Determination of creatine kinase isoenzyme MB activity in serum using immunological inhibition of creatine kinase M subunit activity. Activity kinetics and diagnostic significance in myocardial infarction.  |  Neumeier, D., et al. 1976. Clin Chim Acta. 73: 445-51. PMID: 1000863
2. Alterations in the expression and activity of creatine kinase-M and mitochondrial creatine kinase subunits in skeletal muscle following prolonged intense exercise in rats.  |  Chen, Y., et al. 2000. Eur J Appl Physiol. 81: 114-9. PMID: 10552275
3. Putative creatine kinase M-isoform in human sperm is identifiedas the 70-kilodalton heat shock protein HspA2.  |  Huszar, G., et al. 2000. Biol Reprod. 63: 925-32. PMID: 10952940
4. Prospective analysis of creatine kinase muscle-brain fraction and comparison with troponin T to predict cardiac risk and benefit of an invasive strategy in patients with non-ST-elevation acute coronary syndromes.  |  Kleiman, NS., et al. 2002. J Am Coll Cardiol. 40: 1044-50. PMID: 12354426
5. A long-range restriction map of the human chromosome 19q13 region: close physical linkage between CKMM and the ERCC1 and ERCC2 genes.  |  Smeets, H., et al. 1990. Am J Hum Genet. 46: 492-501. PMID: 2309701
6. Levels of C-reactive protein, creatine kinase-muscle and aldolase A are suitable biomarkers to detect the risk factors for osteoarthritic disorders: A novel diagnostic protocol.  |  Ganguly, A. 2019. Caspian J Intern Med. 10: 25-35. PMID: 30858938
7. Indices for the age of the creatine kinase M-chain in the blood.  |  Wevers, RA., et al. 1985. Clin Chim Acta. 148: 197-210. PMID: 4042354
8. Changes in creatine kinase M localization in acute ischemic myocardial cells. Immunoelectron microscopic studies.  |  Otsu, N., et al. 1993. Circ Res. 73: 935-42. PMID: 8403263
9. Different regulatory sequences control creatine kinase-M gene expression in directly injected skeletal and cardiac muscle.  |  Vincent, CK., et al. 1993. Mol Cell Biol. 13: 1264-72. PMID: 8423791
10. Biochemical markers of early and late spermatogenesis: relationship between the lactate dehydrogenase-X and creatine kinase-M isoform concentrations in human spermatozoa.  |  Lalwani, S., et al. 1996. Mol Reprod Dev. 43: 495-502. PMID: 9052941

The preferred creatine kinase-M antibody is creatine kinase-M Antibody (G-9): sc-365046.