CAP-18 Antibody (G-1): sc-166055

CAP-18 Antibody (G-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects CAP-18 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CAP-18 (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CAP-18, also known as cathelicidin antimicrobial peptide, plays a crucial role in the innate immune response by acting as an antimicrobial agent that helps to prevent infections and modulate inflammation. CAP-18 is primarily expressed in neutrophils, bone marrow, and testis, and is particularly important in inflammatory skin diseases such as psoriasis and dermatitis, where CAP-18 is found in elevated levels. CAP-18 contains the antibacterial peptide LL-37, which is known for its ability to adopt an amphipathic α-helical conformation, allowing CAP-18 to interact effectively with bacterial lipopolysaccharides and recruit immune cells to sites of infection. The presence of LL-37 in inflammatory conditions highlights CAP-18′s significance in host defense mechanisms, making anti-CAP-18 antibody (G-1) an essential tool for researchers studying antimicrobial peptides and their roles in immune responses.

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CAP-18 Antibody (G-1) References:

1. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3.  |  Sørensen, OE., et al. 2001. Blood. 97: 3951-9. PMID: 11389039
2. A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis.  |  Niyonsaba, F., et al. 2002. Immunology. 106: 20-6. PMID: 11972628
3. Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva.  |  Murakami, M., et al. 2002. J Dent Res. 81: 845-50. PMID: 12454100
4. Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response.  |  Dorschner, RA., et al. 2003. Pediatr Res. 53: 566-72. PMID: 12612195
5. Phylogeny, processing and expression of the rat cathelicidin rCRAMP: a model for innate antimicrobial peptides.  |  Termén, S., et al. 2003. Cell Mol Life Sci. 60: 536-49. PMID: 12737313
6. The cathelicidins--structure, function and evolution.  |  Tomasinsig, L. and Zanetti, M. 2005. Curr Protein Pept Sci. 6: 23-34. PMID: 15638766
7. Cathelicidin antimicrobial peptide as a serologic marker and potential pathogenic factor in antineutrophil cytoplasmic antibody-associated vasculitis.  |  Gasim, A. 2014. Arthritis Res Ther. 16: 105. PMID: 25164257
8. Cathelicidin Antimicrobial Peptide Acts as a Tumor Suppressor in Hepatocellular Carcinoma.  |  Huang, LH., et al. 2023. Int J Mol Sci. 24: PMID: 37958632
9. Cathelicidin antimicrobial peptide expression in neutrophils and neurons antagonistically modulates neuroinflammation.  |  Verma, SC., et al. 2024. J Clin Invest. 135: PMID: 39656548
10. A novel murine cathelin-like protein expressed in bone marrow.  |  Popsueva, AE., et al. 1996. FEBS Lett. 391: 5-8. PMID: 8706928
11. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse.  |  Gallo, RL., et al. 1997. J Biol Chem. 272: 13088-93. PMID: 9148921
12. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders.  |  Frohm, M., et al. 1997. J Biol Chem. 272: 15258-63. PMID: 9182550

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CAP-18 Antibody (G-1) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-CAP-18 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CAP-18 Antibody (G-1) Specifications

Alternate Product Name: CAP-18

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 6-175

Epitope Target: CAP-18

Epitope Species: rat

Product Reactivity/Detection: CAP-18

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for CAP-18 Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin