CRALBP Antibody (B2): sc-59487
- CRALBP Antibody (B2) is a mouse monoclonal IgG1 κ, cited in 10 publications, provided at 200 µg/ml
- raised against full length CRALBP of human origin
- Anti-CRALBP Antibody (B2) is recommended for detection of CRALBP of mouse, rat, human and bovine origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CRALBP Antibody (B2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CRALBP Antibody (B2) for WB and IHC(P) applications. These reagents are now offered in bundles with CRALBP Antibody (B2) (see ordering information below).
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CRALBP Antibody (B2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CRALBP in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CRALBP antibody (B2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The cellular retinaldehyde-binding protein (CRALBP) plays a crucial role in the visual cycle by binding to 11-cis-retinol and facilitating its conversion to 11-cis-retinal, which is essential for the phototransduction process in vertebrate photoreceptor cells. CRALBP (B2) monoclonal antibody recognizes CRALBP predominantly in the retinal pigment epithelium and Müller cells, where CRALBP is vital for transporting and recycling visual chromophores, thereby influencing the regeneration of rhodopsin and the overall efficiency of the visual cycle. Mutations in the CRALBP gene can lead to significant retinal pathologies, highlighting its importance in maintaining visual function. CRALBP knockout mice exhibit delayed responses in rhodopsin regeneration and dark adaptation, further underscoring CRALBP′s critical role in visual processing.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CRALBP Antibody (B2) References:
- Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation. | Saari, JC., et al. 2001. Neuron. 29: 739-48. PMID: 11301032
- Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. | McBee, JK., et al. 2001. J Biol Chem. 276: 48483-93. PMID: 11604395
- Assignment of the gene (RLBP1) for cellular retinaldehyde-binding protein (CRALBP) to human chromosome 15q26 and mouse chromosome 7. | Sparkes, RS., et al. 1992. Genomics. 12: 58-62. PMID: 1733864
- Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures. | Crabb, JW., et al. 1988. J Biol Chem. 263: 18688-92. PMID: 3198595
- Molecular cloning and structural analysis of the human gene encoding cellular retinaldehyde-binding protein. | Intres, R., et al. 1994. J Biol Chem. 269: 25411-8. PMID: 7929238
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CRALBP Antibody (B2) | sc-59487 | 200 µg/ml | $316.00 | |||
CRALBP Antibody (B2): m-IgG Fc BP-HRP Bundle | sc-526936 | 200 µg Ab; 10 µg BP | $354.00 | |||
CRALBP Antibody (B2): m-IgG1 BP-HRP Bundle | sc-532309 | 200 µg Ab; 20 µg BP | $354.00 | |||
CRALBP Antibody (B2) AC | sc-59487 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CRALBP Antibody (B2) HRP | sc-59487 HRP | 200 µg/ml | $316.00 | |||
CRALBP Antibody (B2) FITC | sc-59487 FITC | 200 µg/ml | $330.00 | |||
CRALBP Antibody (B2) PE | sc-59487 PE | 200 µg/ml | $343.00 | |||
CRALBP Antibody (B2) Alexa Fluor® 488 | sc-59487 AF488 | 200 µg/ml | $357.00 | |||
CRALBP Antibody (B2) Alexa Fluor® 546 | sc-59487 AF546 | 200 µg/ml | $357.00 | |||
CRALBP Antibody (B2) Alexa Fluor® 594 | sc-59487 AF594 | 200 µg/ml | $357.00 | |||
CRALBP Antibody (B2) Alexa Fluor® 647 | sc-59487 AF647 | 200 µg/ml | $357.00 | |||
CRALBP Antibody (B2) Alexa Fluor® 680 | sc-59487 AF680 | 200 µg/ml | $357.00 | |||
CRALBP Antibody (B2) Alexa Fluor® 790 | sc-59487 AF790 | 200 µg/ml | $357.00 |