CPT1-C Antibody (B-1): sc-514555

CPT1-C Antibody (B-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects CPT1-C protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CPT1-C (B-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CPT1-C protein, also known as carnitine palmitoyltransferase 1C, plays a crucial role in lipid metabolism by facilitating the transport of long-chain fatty acids into the mitochondria for β-oxidation, a vital process for energy production. CPT1-C is primarily expressed in the testis and brain, where CPT1-C exists as three alternatively spliced isoforms encoded by a gene located on human chromosome 19q13.33. CPT1-C functions as a rate-limiting enzyme in the transport of fatty acids, which is essential for maintaining cellular energy homeostasis and metabolic flexibility. Through catalyzing the conversion of palmitoyl-CoA and L-carnitine to CoA and L-palmitoylcarnitine, CPT1-C ensures efficient fatty acid utilization for energy, particularly during periods of fasting or increased energy demand.

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CPT1-C Antibody (B-1) References:

1. A novel brain-expressed protein related to carnitine palmitoyltransferase I.  |  Price, N., et al. 2002. Genomics. 80: 433-42. PMID: 12376098
2. Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects.  |  Bonnefont, JP., et al. 2004. Mol Aspects Med. 25: 495-520. PMID: 15363638
3. The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis.  |  Wolfgang, MJ., et al. 2006. Proc Natl Acad Sci U S A. 103: 7282-7. PMID: 16651524
4. The role of hypothalamic malonyl-CoA in energy homeostasis.  |  Wolfgang, MJ. and Lane, MD. 2006. J Biol Chem. 281: 37265-9. PMID: 17018521
5. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.  |  Sierra, AY., et al. 2008. J Biol Chem. 283: 6878-85. PMID: 18192268
6. Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome.  |  Schreurs, M., et al. 2010. Obes Rev. 11: 380-8. PMID: 19694967

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CPT1-C Antibody (B-1) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-CPT1-C Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CPT1-C Antibody (B-1) Specifications

Alternate Product Name: CPT1-C

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 8-27

Epitope Target: CPT1-C

Epitope Species: human

Product Reactivity/Detection: CPT1-C

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for CPT1-C Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin