CPT1-C Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $188.00 | ||
Rac Perhexiline Maleate exhibits intriguing properties as a CPT1-C inhibitor, characterized by its ability to modulate fatty acid metabolism through specific binding interactions. Its unique stereochemistry facilitates differential binding affinities, influencing metabolic pathways. The compound's hydrophobic regions promote interactions with lipid membranes, altering membrane fluidity and dynamics. Furthermore, its solubility profile in various solvents enhances its reactivity, allowing for diverse chemical transformations. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Etomoxir is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT1), the enzyme responsible for the transport of long-chain fatty acids into the mitochondria for β-oxidation. Inhibition of CPT1 by Etomoxir reduces fatty acid uptake, thereby indirectly modulating CPT1-C action. | ||||||
1-(2,3,4-Trimethoxybenzyl)piperazine | 5011-34-7 | sc-297236 | 500 mg | $374.00 | ||
Trimetazidine inhibits the oxidation of long-chain fatty acids by blocking the activity of 3-ketoacyl CoA thiolase. This results in a shift in cardiac energy metabolism from fatty acids to glucose, indirectly affecting CPT1-C. | ||||||
Ranolazine | 95635-55-5 | sc-212769 | 1 g | $109.00 | 3 | |
Ranolazine inhibits fatty acid β-oxidation, leading to a shift in the heart's energy substrate from fatty acids to glucose. As CPT1-C is involved in the transport of long-chain fatty acids into the mitochondria for β-oxidation, this shift can indirectly affect CPT1-C. | ||||||
4-Hydroxy-L-phenylglycine | 32462-30-9 | sc-254680A sc-254680 | 5 g 10 g | $82.00 $109.00 | ||
Also called Oxfenicine, this compound is a liver-selective CPT1 inhibitor. By inhibiting CPT1 in the liver, Oxfenicine can indirectly affect CPT1-C activity by limiting the overall process of fatty acid oxidation. | ||||||
Meldonium | 76144-81-5 | sc-207887 | 100 mg | $455.00 | 1 | |
Meldonium inhibits the synthesis of carnitine, which is required for the transport of long-chain fatty acids into the mitochondria. By reducing carnitine levels, Mildronate can indirectly inhibit CPT1-C. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine, although primarily known for its role in facilitating the transport of fatty acids into the mitochondria, in high concentrations, can act as an inhibitor of CPT1 by competitive inhibition, thus indirectly affecting CPT1-C. | ||||||
trans-2,3-Dimethylacrylic acid | 80-59-1 | sc-251272 | 100 g | $87.00 | ||
Also called Tiglic acid, this compound is an inhibitor of CPT1. By inhibiting CPT1, Tiglic acid can indirectly affect CPT1-C activity by limiting the overall process of fatty acid oxidation. | ||||||