CPE Antibody (H-6): sc-393760
- CPE Antibody (H-6) is a mouse monoclonal IgG1 κ CPE antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 171-199 near the N-terminus of CPE of mouse origin
- CPE Antibody (H-6) is recommended for detection of precursor and mature CPE of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-CPE Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CPE Antibody (H-6) for WB applications. These reagents are now offered in bundles with CPE Antibody (H-6) (see ordering information below).
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SEE ALSO...
CPE Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CPE protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CPE antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Carboxypeptidase E (CPE) plays a critical role in prohormone processing, specifically in removing C-terminal arginine or lysine residues following initial endoprotease cleavage. This function is essential for proper maturation of peptide hormones, including insulin, which is vital for glucose metabolism and energy homeostasis. CPE is necessary for forming normal-sized photoreceptor synaptic terminals, ensuring effective signal transmission to the inner retina, which is crucial for visual processing. The tetrameric structure of CPE, composed of two regulatory and two catalytic subunits, allows for precise enzymatic activity, further underscoring CPE′s importance in various physiological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CPE Antibody (H-6) References:
- Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells. | Marzban, L., et al. 2005. Endocrinology. 146: 1808-17. PMID: 15618358
- Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e. | Lou, H., et al. 2005. Neuron. 45: 245-55. PMID: 15664176
- Augmented responses to ozone in obese carboxypeptidase E-deficient mice. | Johnston, RA., et al. 2006. Am J Physiol Regul Integr Comp Physiol. 290: R126-33. PMID: 16002559
- Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina. | Zhu, X., et al. 2005. J Neurochem. 95: 1351-62. PMID: 16219026
- Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. | Hosaka, M., et al. 2005. J Cell Sci. 118: 4785-95. PMID: 16219686
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CPE Antibody (H-6) | sc-393760 | 200 µg/ml | $322.00 | |||
CPE Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-530572 | 200 µg Ab; 10 µg BP | $361.00 | |||
CPE Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-524080 | 200 µg Ab, 40 µg BP | $361.00 | |||
CPE Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-544138 | 200 µg Ab; 20 µg BP | $361.00 | |||
CPE Antibody (H-6) AC | sc-393760 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CPE Antibody (H-6) HRP | sc-393760 HRP | 200 µg/ml | $322.00 | |||
CPE Antibody (H-6) FITC | sc-393760 FITC | 200 µg/ml | $336.00 | |||
CPE Antibody (H-6) PE | sc-393760 PE | 200 µg/ml | $349.00 | |||
CPE Antibody (H-6) Alexa Fluor® 488 | sc-393760 AF488 | 200 µg/ml | $364.00 | |||
CPE Antibody (H-6) Alexa Fluor® 546 | sc-393760 AF546 | 200 µg/ml | $364.00 | |||
CPE Antibody (H-6) Alexa Fluor® 594 | sc-393760 AF594 | 200 µg/ml | $364.00 | |||
CPE Antibody (H-6) Alexa Fluor® 647 | sc-393760 AF647 | 200 µg/ml | $364.00 | |||
CPE Antibody (H-6) Alexa Fluor® 680 | sc-393760 AF680 | 200 µg/ml | $364.00 | |||
CPE Antibody (H-6) Alexa Fluor® 790 | sc-393760 AF790 | 200 µg/ml | $364.00 | |||
CPE (H-6) Neutralizing Peptide | sc-393760 P | 100 µg/0.5 ml | $69.00 |