COX6c Antibody (H-9): sc-390414
- COX6c Antibody (H-9) is a mouse monoclonal IgG2a κ COX6c antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-75 representing full length COX6c of human origin
- COX6c Antibody (H-9) is recommended for detection of COX6c of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-COX6c Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for COX6c Antibody (H-9) for WB and IHC(P) applications. These reagents are now offered in bundles with COX6c Antibody (H-9) (see ordering information below).
COX6c Antibody (H-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects COX6c protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). COX6c (H-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COX6c protein, also known as cytochrome c oxidase subunit VIc, is a crucial component of the mitochondrial respiratory chain, specifically part of the oxidative phosphorylation complex IV. COX6c plays a vital role in cellular respiration by facilitating the reduction of molecular oxygen to water, a process essential for ATP generation through the electron transport chain. COX6c subunit is encoded by nuclear genes and is integral to the assembly and regulation of the larger enzyme complex, which consists of 13 subunits, including those encoded by mitochondrial DNA. Proper functioning of COX6c is critical for maintaining the electrochemical gradient across the mitochondrial inner membrane, necessary for ATP synthesis. Human COX6c protein exhibits 77% sequence identity with its mouse counterpart, and research has shown that COX6c gene is upregulated in prostate cancer cells, indicating a potential role in cancer biology. Human COX6c gene is located on chromosome 8q22.2, with a pseudogene, COX6CP1, identified on chromosome 16p12.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COX6c Antibody (H-9) References:
- Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma. | Kurose, K., et al. 2000. Genes Chromosomes Cancer. 27: 303-7. PMID: 10679920
- Cytochrome oxidase in health and disease. | Barrientos, A., et al. 2002. Gene. 286: 53-63. PMID: 11943460
- Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. | Sirchia, R. and Luparello, C. 2007. Biol Chem. 388: 457-65. PMID: 17516841
- Separation of mammalian cytochrome c oxidase into 13 polypeptides by a sodium dodecyl sulfate-gel electrophoretic procedure. | Kadenbach, B., et al. 1983. Anal Biochem. 129: 517-21. PMID: 6303162
- Structure of cytochrome c oxidase. | Capaldi, RA., et al. 1983. Biochim Biophys Acta. 726: 135-48. PMID: 6307356
- Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. | Hofmann, S., et al. 1998. Cytogenet Cell Genet. 83: 226-7. PMID: 10072584
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COX6c Antibody (H-9) | sc-390414 | 200 µg/ml | $322.00 | |||
COX6c Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-530149 | 200 µg Ab; 10 µg BP | $361.00 | |||
COX6c Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-523525 | 200 µg Ab, 40 µg BP | $361.00 | |||
COX6c Antibody (H-9): m-IgG2a BP-HRP Bundle | sc-547445 | 200 µg Ab; 10 µg BP | $361.00 | |||
COX6c Antibody (H-9) AC | sc-390414 AC | 500 µg/ml, 25% agarose | $424.00 | |||
COX6c Antibody (H-9) HRP | sc-390414 HRP | 200 µg/ml | $322.00 | |||
COX6c Antibody (H-9) FITC | sc-390414 FITC | 200 µg/ml | $336.00 | |||
COX6c Antibody (H-9) PE | sc-390414 PE | 200 µg/ml | $349.00 | |||
COX6c Antibody (H-9) Alexa Fluor® 488 | sc-390414 AF488 | 200 µg/ml | $364.00 | |||
COX6c Antibody (H-9) Alexa Fluor® 546 | sc-390414 AF546 | 200 µg/ml | $364.00 | |||
COX6c Antibody (H-9) Alexa Fluor® 594 | sc-390414 AF594 | 200 µg/ml | $364.00 | |||
COX6c Antibody (H-9) Alexa Fluor® 647 | sc-390414 AF647 | 200 µg/ml | $364.00 | |||
COX6c Antibody (H-9) Alexa Fluor® 680 | sc-390414 AF680 | 200 µg/ml | $364.00 | |||
COX6c Antibody (H-9) Alexa Fluor® 790 | sc-390414 AF790 | 200 µg/ml | $364.00 |