COUP-TFI Antibody (G-6): sc-74560

COUP-TFI Antibody (G-6) is a mouse monoclonal IgG2a antibody that detects COUP-TFI in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COUP-TFI, also known as chicken ovalbumin upstream promoter transcription factor I, plays a crucial role in regulating gene expression during development, particularly in the central nervous system. COUP-TFI is primarily located in the nucleus, where COUP-TFI binds to specific DNA response elements, influencing the transcription of target genes involved in neural differentiation and development. COUP-TFI′s ability to compete with other nuclear receptors, such as retinoic acid receptors and peroxisome proliferator-activated receptors, highlights COUP-TFI′s importance in maintaining the balance of gene expression necessary for proper cellular function. Additionally, COUP-TFI undergoes post-translational modifications, including phosphorylation, which can affect COUP-TFI′s activity and stability, further underscoring COUP-TFI′s regulatory role in various biological processes. With significant involvement in neural development and transcriptional regulation, anti-COUP-TFI antibody (G-6) serves as an essential tool for researchers studying gene expression and developmental biology.

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COUP-TFI Antibody (G-6) References:

1. COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.  |  Alfano, C., et al. 2011. Development. 138: 4685-97. PMID: 21965613
2. COUP-TFI controls activity-dependent tyrosine hydroxylase expression in adult dopaminergic olfactory bulb interneurons.  |  Bovetti, S., et al. 2013. Development. 140: 4850-9. PMID: 24227652
3. COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration.  |  Boudot, A., et al. 2014. BMC Cancer. 14: 407. PMID: 24906407
4. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb.  |  Zhou, X., et al. 2015. Development. 142: 1593-605. PMID: 25922524
5. COUP-TFI mitotically regulates production and migration of dentate granule cells and modulates hippocampal Cxcr4 expression.  |  Parisot, J., et al. 2017. Development. 144: 2045-2058. PMID: 28506990
6. The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.  |  Alzu'bi, A., et al. 2017. Cereb Cortex. 27: 4971-4987. PMID: 28922831
7. The pleiotropic transcriptional regulator COUP-TFI plays multiple roles in neural development and disease.  |  Bertacchi, M., et al. 2019. Brain Res. 1705: 75-94. PMID: 29709504
8. Activation of COUP-TFI by a Novel Diindolylmethane Derivative.  |  Yoon, K., et al. 2019. Cells. 8: PMID: 30866413
9. COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex.  |  Del Pino, I., et al. 2020. Cereb Cortex. 30: 5667-5685. PMID: 32572460
10. Regulation of Axon Initial Segment Diameter by COUP-TFI Fine-tunes Action Potential Generation.  |  Wu, X., et al. 2022. Neurosci Bull. 38: 505-518. PMID: 34773220

The preferred COUP-TFI antibody is COUP-TFI Antibody (H-11): sc-74561.