Cosmc Antibody (H-10): sc-271829
- Cosmc Antibody (H-10) is a mouse monoclonal IgG1 κ Cosmc antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 1-270 mapping at the N-terminus of Cosmc of human origin
- Cosmc Antibody (H-10) is recommended for detection of Cosmc of human origin by WB, IP, IF and ELISA
- Anti-Cosmc Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cosmc Antibody (H-10) for WB applications. These reagents are now offered in bundles with Cosmc Antibody (H-10) (see ordering information below).
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SEE ALSO...
Cosmc Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cosmc protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Cosmc antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cosmc protein, also known as C1GALT1-specific chaperone 1, consists of 318 amino acids and is encoded by the human gene C1GALT1C1. Cosmc plays a crucial role in the synthesis of O-glycans, specifically the Tn antigen, which serves as a precursor for more complex O-glycans found in glycoproteins. Proper functioning of Cosmc is vital for correct glycosylation of proteins, as defects in this process can lead to the development of Tn syndrome, a rare autoimmune disorder characterized by incompletely glycosylated Tn antigens on blood cells, resulting in anemia, leukopenia, and thrombocytopenia. Cosmc is a single-pass type II membrane protein widely expressed across various tissues, with highest levels found in the small intestine, stomach, salivary glands, kidneys, and testes, as well as moderate expression in the brain, thymus, spleen, and lungs. Understanding Cosmc′s function and importance in glycosylation pathways is essential for researchers studying autoimmune diseases and glycoprotein biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cosmc Antibody (H-10) References:
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. | Zhang, QH., et al. 2000. Genome Res. 10: 1546-60. PMID: 11042152
- Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan. | Kudo, T., et al. 2002. J Biol Chem. 277: 47724-31. PMID: 12361956
- A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. | Ju, T. and Cummings, RD. 2002. Proc Natl Acad Sci U S A. 99: 16613-8. PMID: 12464682
- Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression in immunoglobulin A nephropathy. | Qin, W., et al. 2005. J Intern Med. 258: 467-77. PMID: 16238683
- Protein glycosylation: chaperone mutation in Tn syndrome. | Ju, T. and Cummings, RD. 2005. Nature. 437: 1252. PMID: 16251947
- Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans. | Ju, T., et al. 2006. Glycobiology. 16: 947-58. PMID: 16762980
- A mutant chaperone converts a wild-type protein into a tumor-specific antigen. | Schietinger, A., et al. 2006. Science. 314: 304-8. PMID: 17038624
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cosmc Antibody (H-10) | sc-271829 | 200 µg/ml | $322.00 | |||
Cosmc Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-529268 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cosmc Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-522072 | 200 µg Ab, 40 µg BP | $361.00 | |||
Cosmc Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-543423 | 200 µg Ab; 20 µg BP | $361.00 | |||
Cosmc Antibody (H-10) AC | sc-271829 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Cosmc Antibody (H-10) HRP | sc-271829 HRP | 200 µg/ml | $322.00 | |||
Cosmc Antibody (H-10) FITC | sc-271829 FITC | 200 µg/ml | $336.00 | |||
Cosmc Antibody (H-10) PE | sc-271829 PE | 200 µg/ml | $349.00 | |||
Cosmc Antibody (H-10) Alexa Fluor® 488 | sc-271829 AF488 | 200 µg/ml | $364.00 | |||
Cosmc Antibody (H-10) Alexa Fluor® 546 | sc-271829 AF546 | 200 µg/ml | $364.00 | |||
Cosmc Antibody (H-10) Alexa Fluor® 594 | sc-271829 AF594 | 200 µg/ml | $364.00 | |||
Cosmc Antibody (H-10) Alexa Fluor® 647 | sc-271829 AF647 | 200 µg/ml | $364.00 | |||
Cosmc Antibody (H-10) Alexa Fluor® 680 | sc-271829 AF680 | 200 µg/ml | $364.00 | |||
Cosmc Antibody (H-10) Alexa Fluor® 790 | sc-271829 AF790 | 200 µg/ml | $364.00 | |||
Cosmc Antibody (H-10) B | sc-271829 B | 200 µg/ml | $326.00 |