Coronin 2A Antibody (A-3): sc-271873

Coronin 2A Antibody (A-3) is a mouse monoclonal IgG1 antibody that detects Coronin 2A in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Coronin 2A, also known as CLIPINB or IR10, plays a crucial role in cellular processes by being a key component of the approximately 1.5-2 megadalton nuclear receptor corepressor (N-CoR) complex, which consists of 10-12 proteins that recruit histone deacetylases to generate repressive chromatin. This function is vital for regulating gene expression and maintaining cellular homeostasis, as Coronin 2A influences the transcriptional repression of target genes. The presence of Coronin 2A in this complex underscores its importance in modulating cellular responses to various signals, thereby impacting processes such as differentiation and development. Additionally, Coronin 2A exhibits a conserved basic N-terminal motif and multiple WD repeats, which are essential for structural integrity and functional interactions within the cell. With anti-Coronin 2A antibody (A-3)′s ability to participate in critical cellular mechanisms, this research tool proves valuable for investigating the dynamics of gene regulation and chromatin remodeling in various biological contexts.

The preferred Coronin 2A antibody is Coronin 2A Antibody (H-2): sc-376194.