cornulin Antibody (A-3): sc-514602
- cornulin Antibody (A-3) is a mouse monoclonal IgG1 κ cornulin antibody provided at 200 µg/ml
- raised against amino acids 32-92 mapping near the N-terminus of cornulin of human origin
- cornulin Antibody (A-3) is recommended for detection of cornulin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-cornulin Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cornulin Antibody (A-3) for WB applications. These reagents are now offered in bundles with cornulin Antibody (A-3) (see ordering information below).
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Cornulin Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects cornulin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cornulin antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cornulin, also referred to as tumor-related protein, CRNN, SEP53 (squamous epithelial heat shock protein 53), DRC1, or PDRC1, is a 495 amino acid cytoplasmic protein that plays a crucial role in epidermal differentiation and epithelial immune response. Cornulin is specifically expressed in squamous epithelial cells, including those found in esophagus, cultured primary keratinocytes, scalp skin, foreskin, and fetal bladder. Cornulin′s structure shares homology with S-100 proteins, profilaggrin, Repetin, and Trichohyalin, suggesting potential as a marker for late epidermal differentiation and cancer development. Cornulin is upregulated by deoxycholic acid, heat shock, and ponasterone A, and contains one EF-hand domain, which is vital for protecting cells from deoxycholic acid-induced death. The gene encoding cornulin is located on human chromosome 1q21.3 and mouse chromosome 3 F2.1, highlighting evolutionary conservation and significance in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cornulin Antibody (A-3) References:
- Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer. | Xu, Z., et al. 2000. Genomics. 69: 322-30. PMID: 11056050
- Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation. | Contzler, R., et al. 2005. J Invest Dermatol. 124: 990-7. PMID: 15854041
- An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses. | Nelson, L., et al. 2008. Cell Stress Chaperones. 13: 375-85. PMID: 18465210
- Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema. | Liedén, A., et al. 2009. Allergy. 64: 304-11. PMID: 19133922
- Genetic variants of C1orf10 and risk of esophageal squamous cell carcinoma in a Chinese population. | Zhang, W., et al. 2009. Cancer Sci. 100: 1695-700. PMID: 19558548
- Common variants in the trichohyalin gene are associated with straight hair in Europeans. | Medland, SE., et al. 2009. Am J Hum Genet. 85: 750-5. PMID: 19896111
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cornulin Antibody (A-3) | sc-514602 | 200 µg/ml | $322.00 | |||
cornulin Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-531174 | 200 µg Ab; 10 µg BP | $361.00 | |||
cornulin Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-524788 | 200 µg Ab, 40 µg BP | $361.00 | |||
cornulin Antibody (A-3): m-IgG1 BP-HRP Bundle | sc-544423 | 200 µg Ab; 20 µg BP | $361.00 | |||
cornulin Antibody (A-3) AC | sc-514602 AC | 500 µg/ml, 25% agarose | $424.00 | |||
cornulin Antibody (A-3) HRP | sc-514602 HRP | 200 µg/ml | $322.00 | |||
cornulin Antibody (A-3) FITC | sc-514602 FITC | 200 µg/ml | $336.00 | |||
cornulin Antibody (A-3) PE | sc-514602 PE | 200 µg/ml | $349.00 | |||
cornulin Antibody (A-3) Alexa Fluor® 488 | sc-514602 AF488 | 200 µg/ml | $364.00 | |||
cornulin Antibody (A-3) Alexa Fluor® 546 | sc-514602 AF546 | 200 µg/ml | $364.00 | |||
cornulin Antibody (A-3) Alexa Fluor® 594 | sc-514602 AF594 | 200 µg/ml | $364.00 | |||
cornulin Antibody (A-3) Alexa Fluor® 647 | sc-514602 AF647 | 200 µg/ml | $364.00 | |||
cornulin Antibody (A-3) Alexa Fluor® 680 | sc-514602 AF680 | 200 µg/ml | $364.00 | |||
cornulin Antibody (A-3) Alexa Fluor® 790 | sc-514602 AF790 | 200 µg/ml | $364.00 |