COQ7 Antibody (F-9): sc-376484

COQ7 Antibody (F-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects COQ7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). COQ7 Antibody (F-9) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COQ7, a homolog of the Timing protein CLK-1, consists of 217 amino acids and is encoded by the mouse gene Coq7. COQ7 plays a crucial role in the biosynthesis of Coenzyme Q (CoQ), an essential co-factor in mitochondrial respiration, vital for energy production in cells. COQ7′s importance is underscored by involvement in maintaining mitochondrial integrity and supporting neurogenesis, particularly in tissues with high energy demands such as heart, muscle, liver, and kidney. Following transcription, COQ7 is directed to mitochondria, where processing achieves mature form. Conservation of function among CLK-1/clk-1/COQ7 gene products suggests a significant link between ubiquinone production and aging process, highlighting potential implications in age-related mitochondrial dysfunction.

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COQ7 Antibody (F-9) References:

1. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging.  |  Vajo, Z., et al. 1999. Mamm Genome. 10: 1000-4. PMID: 10501970
2. A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.  |  Stenmark, P., et al. 2001. J Biol Chem. 276: 33297-300. PMID: 11435415
3. Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans.  |  Takahashi, M., et al. 2001. Biochem Biophys Res Commun. 286: 534-40. PMID: 11511092
4. Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration.  |  Levavasseur, F., et al. 2001. J Biol Chem. 276: 46160-4. PMID: 11585841
5. Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis.  |  Nakai, D., et al. 2001. Biochem Biophys Res Commun. 289: 463-71. PMID: 11716496
6. coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q.  |  Nakai, D., et al. 2004. Aging Cell. 3: 273-81. PMID: 15379851
7. The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration.  |  Barros, MH., et al. 2005. J Biol Chem. 280: 42627-35. PMID: 16230336
8. Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis.  |  Tran, UC., et al. 2006. J Biol Chem. 281: 16401-9. PMID: 16624818
9. Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines.  |  Brea-Calvo, G., et al. 2006. Free Radic Biol Med. 40: 1293-302. PMID: 16631519

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COQ7 Antibody (F-9) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-COQ7 Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COQ7 Antibody (F-9) Specifications

Alternate Product Name: COQ7

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-217

Epitope Target: COQ7

Epitope Species: human

Product Reactivity/Detection: COQ7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for COQ7 Antibody (F-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin