connexin 43 Antibody (F-7): sc-271837

Connexin 43 Antibody (F-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects connexin 43 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-connexin 43 antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Connexin 43, also known as gap junction protein alpha 1 or GJA1, plays a crucial role in cell communication by forming gap junctions that allow the passage of ions and small molecules between adjacent cells, which is essential for maintaining tissue homeostasis and coordinating cellular responses. Connexin 43 is primarily located in the plasma membrane of various cell types, including cardiac and neuronal cells, where connexin 43 facilitates intercellular communication. This localization enables rapid signaling and metabolic cooperation between cells, which is particularly important in tissues that require synchronized activity, such as the heart. Disruption of connexin 43 expression or function has been linked to various pathological conditions, including cardiac arrhythmias and neurodegenerative diseases, highlighting connexin 43′s significance in both normal physiology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-connexin 43 Antibody (F-7) has 57 citations in a variety of scientific publications.

Primary antibodies like Anti-connexin 43 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

connexin 43 Antibody (F-7) Specifications

Alternate Product Name: GJA1

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 357-381

Epitope Target: connexin 43

Epitope Species: human

Product Reactivity/Detection: connexin 43

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 57 citations in various scientific publications

Available Conjugates/Forms for connexin 43 Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred connexin 43 antibody is connexin 43 Antibody (D-7): sc-13558.