Connexin 43 Inhibitors
Connexin 43 (Cx43) inhibitors represent a unique class of chemical compounds that specifically target and inhibit the function of connexin 43, a protein that forms gap junction channels in cell membranes. Connexin 43 is one of the most ubiquitously expressed types among the connexin family, which consists of more than 20 isoforms in humans. These proteins are critical in facilitating direct, cytoplasm-to-cytoplasm communication between adjacent cells, allowing the passage of various small molecules and ions. This communication is crucial in maintaining tissue homeostasis and coordinating cellular activities.
The inhibitors of Cx43 come in various forms and structures, ranging from mimetic peptides to non-steroidal anti-inflammatory drugs (NSAIDs), alcohols, and even certain natural and synthetic compounds. The mimetic peptides, such as Gap26 and Gap27, are designed to mimic sequences in the extracellular loop of Cx43, blocking the formation of complete gap junction channels and reducing intercellular communication. Some NSAIDs, like meclofenamic acid and flufenamic acid, inhibit Cx43 by blocking the channel pore. Certain alcohols, like heptanol and octanol, disrupt the lipid bilayer of the cell membrane, thus impeding the function of gap junction channels including Cx43. Other compounds, such as carbenoxolone and its derivatives, bind to connexin proteins and interfere with channel pore formation, thus inhibiting Cx43.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbenoxolone disodium | 7421-40-1 | sc-203868 sc-203868A sc-203868B sc-203868C | 1 g 5 g 10 g 25 g | $45.00 $197.00 $351.00 $759.00 | 1 | |
Carbenoxolone is a glycyrrhetinic acid derivative that inhibits connexin 43 by blocking gap junction intercellular communication. It binds to the connexin proteins and interferes with channel pore formation. | ||||||
18α-Glycyrrhetinic acid | 1449-05-4 | sc-223188 sc-223188A | 250 mg 1 g | $102.00 $359.00 | 1 | |
Similar to Carbenoxolone, 18α-Glycyrrhetinic Acid is a derivative of glycyrrhetinic acid. It inhibits Cx43 by blocking the gap junction communication, affecting the channel pore formation. | ||||||
1-Heptanol | 111-70-6 | sc-237561 | 100 ml | $111.00 | ||
Heptanol is an aliphatic alcohol that inhibits connexin 43 by blocking gap junction intercellular communication. This non-specific inhibitor affects the lipid bilayer of the cell membrane, disrupting the function of gap junction channels. | ||||||
1-Octanol | 111-87-5 | sc-255858 | 1 ml | $45.00 | ||
Octanol works similarly to Heptanol. It is an aliphatic alcohol that disrupts the lipid bilayer of the cell membrane, thereby inhibiting the function of gap junction channels, including Cx43. | ||||||
Meclofenamic Acid | 644-62-2 | sc-211780 | 5 mg | $394.00 | ||
Meclofenamic acid is a nonsteroidal anti-inflammatory drug that inhibits Cx43 hemichannels. It does this by blocking the channel pore, preventing the exchange of ions and small molecules. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
Flufenamic acid is another nonsteroidal anti-inflammatory drug that inhibits Cx43. It acts by blocking the channel pore, preventing intercellular communication. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is a natural alkaloid that inhibits Cx43. It blocks the gap junction intercellular communication by interacting with the channel pore, preventing the exchange of ions and small molecules. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid is a uricosuric agent that can inhibit connexin 43. It blocks the hemichannels, disrupting the intercellular communication. | ||||||
Lanthanum(III) chloride | 10099-58-8 | sc-257661 | 10 g | $88.00 | ||
Lanthanum Chloride is a gap junction blocker that inhibits Cx43 by interacting with the channel pore. It prevents the exchange of ions and other small molecules, disrupting gap junction communication. | ||||||