connexin 40 Antibody (B-3): sc-365107

connexin 40 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects connexin 40 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-connexin 40 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Connexin 40, also known as gap junction protein alpha 5, plays a crucial role in intercellular communication by forming gap junctions that allow the passage of ions and small molecules between adjacent cells. This function is particularly important in cardiac tissue, where connexin 40 facilitates electrical coupling between cardiomyocytes, thereby contributing to synchronized heart contractions. Disruptions in connexin 40 expression or function can lead to various cardiac arrhythmias, highlighting connexin 40′s significance in maintaining normal heart rhythm. Studies have shown that increased levels of connexin 40 following cardiac surgery can indicate a higher risk of post-operative atrial fibrillation, making connexin 40 a valuable marker for assessing cardiac health.

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connexin 40 Antibody (B-3) References:

1. Molecular analysis of connexin 40 in the familial form of atrial fibrillation.  |  Lamarche, J., et al. 2001. Eur Heart J. 22: 1511-2. PMID: 11482925
2. Emerging issues of connexin channels: biophysics fills the gap.  |  Harris, AL. 2001. Q Rev Biophys. 34: 325-472. PMID: 11838236
3. Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40.  |  Dhein, S., et al. 2002. Biol Cell. 94: 409-22. PMID: 12566216
4. Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion.  |  de Wit, C., et al. 2003. Physiol Genomics. 13: 169-77. PMID: 12700362
5. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation.  |  Gollob, MH., et al. 2006. N Engl J Med. 354: 2677-88. PMID: 16790700
6. Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension.  |  Wagner, C., et al. 2010. Kidney Int. 78: 762-8. PMID: 20686449
7. Lack of connexin 40 decreases the calcium sensitivity of renin-secreting juxtaglomerular cells.  |  Steppan, D., et al. 2018. Pflugers Arch. 470: 969-978. PMID: 29427253
8. Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.  |  Yin, J., et al. 2019. Am J Physiol Lung Cell Mol Physiol. 316: L35-L44. PMID: 30234377
9. Human cardiac gap junctions: isolation, ultrastructure, and protein composition.  |  Manjunath, CK., et al. 1987. J Mol Cell Cardiol. 19: 131-4. PMID: 3573042
10. Advanced Glycation End Products Downregulate Connexin 43 and Connexin 40 in Diabetic Atrial Myocytes via the AMPK Pathway.  |  Yang, F., et al. 2023. Diabetes Metab Syndr Obes. 16: 3045-3056. PMID: 37810573
11. Decreased connexin expression and intercellular communication in human bladder cancer cells.  |  Grossman, HB., et al. 1994. Cancer Res. 54: 3062-5. PMID: 8187096

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-connexin 40 Antibody (B-3) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-connexin 40 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

connexin 40 Antibody (B-3) Specifications

Alternate Product Name: GJA5

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 231-346

Epitope Target: connexin 40

Epitope Species: human

Product Reactivity/Detection: connexin 40

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for connexin 40 Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin