Complexin-3 Antibody (A-9): sc-365942

Complexin-3 Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects Complexin-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Complexin-3, also known as CPXIII, CPX-III, Nbla11589, or CPLX3, is a 158 amino acid protein that plays a crucial role in regulating synaptic vesicle exocytosis, a vital process for neurotransmitter release in the nervous system. Complexin-3 is primarily located in presynaptic terminals of neurons, where anti-Complexin-3 antibody (A-9) can detect binding to the SNARE core complex, which includes SNAP-25, VAMP-2, and Syntaxin 1. Complexin-3′s interaction with these proteins is essential for proper synaptic transmission, promoting the formation of SNARE complexes necessary for synaptic vesicle fusion with the presynaptic membrane. By facilitating this process, Complexin-3 ensures efficient neurotransmitter release, critical for communication between neurons. Neurons deficient in Complexin-3 exhibit impaired transmitter release, highlighting Complexin-3′s importance in maintaining synaptic efficacy and overall neuronal function. Complexin-3 (A-9) antibody serves as an invaluable tool for researchers studying synaptic mechanisms and molecular underpinnings of neurotransmission.

The preferred Complexin-3 antibody is Complexin-3 Antibody (C-8): sc-365941.