COMMD7 Antibody (AT49B5): sc-517395

COMMD7 Antibody (AT49B5) is a mouse monoclonal IgG3 kappa light chain antibody that detects COMMD7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). COMMD7 (AT49B5) antibody is available as a non-conjugated anti-COMMD7 antibody. COMMD7, also known as COMM domain-containing protein 7, is a 200 amino acid protein predominantly expressed in the lung, where COMMD7 plays a crucial role in regulating the transcriptional activity of the NFκB complex. By binding to COMMD1 through its COMM domain, COMMD7 inhibits the transcriptional activity of NFκB, which is vital for controlling inflammatory responses and cell survival. This interaction is particularly important as dysregulation of NFκB activity is implicated in various diseases, including cancer and inflammatory disorders. Furthermore, COMMD7 is part of a larger family of COMMD proteins, which participate in diverse cellular processes such as copper homeostasis, cell proliferation, and regulation of the ubiquitin pathway. The unique functions of COMMD7 and its family members underscore their significance in maintaining cellular homeostasis and responding to stress signals, making anti-COMMD7 antibody (AT49B5) an essential tool for researchers studying these critical biological pathways.

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COMMD7 Antibody (AT49B5) References:

1. COMMD proteins, a novel family of structural and functional homologs of MURR1.  |  Burstein, E., et al. 2005. J Biol Chem. 280: 22222-32. PMID: 15799966
2. Characterization of COMMD protein-protein interactions in NF-kappaB signalling.  |  de Bie, P., et al. 2006. Biochem J. 398: 63-71. PMID: 16573520
3. COMMD proteins and the control of the NF kappa B pathway.  |  Maine, GN. and Burstein, E. 2007. Cell Cycle. 6: 672-6. PMID: 17361106
4. Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice.  |  van de Sluis, B., et al. 2007. Mol Cell Biol. 27: 4142-56. PMID: 17371845
5. COMMD proteins: COMMing to the scene.  |  Maine, GN. and Burstein, E. 2007. Cell Mol Life Sci. 64: 1997-2005. PMID: 17497243
6. COMMD1 expression is controlled by critical residues that determine XIAP binding.  |  Maine, GN., et al. 2009. Biochem J. 417: 601-9. PMID: 18795889
7. COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate.  |  Burkhead, JL., et al. 2009. J Biol Chem. 284: 696-707. PMID: 18940794

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COMMD7 Antibody (AT49B5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-COMMD7 Antibody (AT49B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COMMD7 Antibody (AT49B5) Specifications

Alternate Product Name: COMMD7

Product Clone Name: AT49B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-200

Epitope Target: COMMD7

Epitope Species: human

Product Reactivity/Detection: COMMD7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 1% glycerol and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for COMMD7 Antibody (AT49B5): N/A