Date published: 2025-10-23

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COMMD7 Inhibitors

COMMD7 Inhibitors consists of a diverse array of compounds, each characterized by their ability to influence the activity of COMM Domain Containing 7 (COMMD7). This group of inhibitors is identified not by a uniform chemical structure, but rather by their functional potential to modulate the biological activities associated with COMMD7. These compounds play a crucial role in targeting the various pathways and processes in which COMMD7 is implicated, including NF-κB signaling, copper homeostasis, and oxidative stress response. The development and identification of these inhibitors are grounded in a comprehensive understanding of COMMD7's involvement in these critical cellular pathways. The approach to inhibiting COMMD7 encompasses various strategies, each tailored to the distinct aspects of the protein's function. One primary method is targeting the NF-κB signaling pathway, a central route in inflammation and immune response, where COMMD7 plays a regulatory role. By modulating this pathway, these inhibitors can impact the downstream effects mediated by COMMD7, thereby influencing cellular responses to inflammation and stress. Another approach involves the regulation of copper metabolism. Given COMMD7's role in copper homeostasis, compounds that affect copper levels within the cell can indirectly influence the function of COMMD7, thereby affecting its regulatory role in copper-dependent processes. Furthermore, the oxidative stress response, a pathway where COMMD7 might be involved, presents another target. Compounds that modulate the cellular response to oxidative stress can have implications for the function of COMMD7, given its potential role in managing oxidative stress-related pathways. In essence, the class of COMMD7 Inhibitors is defined by compounds with diverse mechanisms of action, each targeting different aspects of the biological pathways and processes associated with COMMD7. The exploration and development of these inhibitors are propelled by ongoing research into the molecular biology of COMMD7, its interaction with various signaling pathways, and its role in cellular processes. Understanding the interactions and functions of COMMD7 at a molecular level is crucial for developing strategies to modulate its activity, which has implications for understanding the complex mechanisms governing cellular regulation, particularly in pathways related to inflammation, immune response, and metal ion homeostasis.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BMS-345541

445430-58-0sc-221741
1 mg
$306.00
1
(1)

Could possibly inhibit COMMD7 by disrupting the NF-κB signaling pathway.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Could possibly inhibit COMMD7 by affecting the degradation pathway of NF-κB.

NFκB Activation Inhibitor II, JSH-23

749886-87-1sc-222061
sc-222061C
sc-222061A
sc-222061B
5 mg
10 mg
50 mg
100 mg
$210.00
$252.00
$1740.00
$1964.00
34
(1)

Could possibly inhibit COMMD7 by directly affecting the NF-κB pathway.

N-Acetyl-L-cysteine

616-91-1sc-202232
sc-202232A
sc-202232C
sc-202232B
5 g
25 g
1 kg
100 g
$33.00
$73.00
$265.00
$112.00
34
(1)

Could possibly inhibit COMMD7 by modulating oxidative stress.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Could possibly inhibit COMMD7 by inhibiting NF-κB activation.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

Could possibly inhibit COMMD7 by affecting MAPK signaling pathways.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

Could possibly inhibit COMMD7 by impacting PI3K-related signaling pathways.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Could possibly inhibit COMMD7 by influencing histone deacetylation and gene expression.

Fludarabine

21679-14-1sc-204755
sc-204755A
5 mg
25 mg
$57.00
$200.00
15
(1)

Could possibly inhibit COMMD7 by impacting cytokine signaling pathways.