COL1A1 Antibody (3G3): sc-293182

COL1A1 Antibody (3G3) is a mouse monoclonal IgG3 kappa light chain antibody that targets Collagen α1 Type I, also known as COL1A1 or type I collagen alpha-1 chain, a vital component of the extracellular matrix (ECM) in various connective tissues. COL1A1 monoclonal antibody (3G3) is raised against a recombinant protein corresponding to amino acids 1021-1108 of human COL1A1, detecting COL1A1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). COL1A1 is predominantly located in the ECM, where it forms fibrillar structures that provide tensile strength and structural integrity to tissues like tendons, skin, and bone. The presence of COL1A1 in the ECM is essential for maintaining tissue architecture, facilitating cell adhesion, and supporting cellular functions such as migration and differentiation. Additionally, COL1A1 plays a significant role in wound healing and tissue repair by contributing to the formation of scar tissue. Anti-COL1A1 antibody (3G3) is available in a non-conjugated form, allowing researchers to incorporate it into various experimental protocols aimed at studying collagen-related processes. COL1A1 monoclonal antibody (3G3) is recommended for researchers studying extracellular matrix dynamics and their implications in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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COL1A1 Antibody (3G3) References:

1. Collagen and bone strength.  |  Boskey, AL., et al. 1999. J Bone Miner Res. 14: 330-5. PMID: 10027897
2. Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways.  |  Alberio, L. and Dale, GL. 1999. Eur J Clin Invest. 29: 1066-76. PMID: 10583456
3. Cell adhesion to collagenous matrices.  |  McCarthy, JB., et al. 1996. Biopolymers. 40: 371-81. PMID: 8765608
4. Nasal tolerance to dominant and subdominant epitopes of collagen type II and protection against collagen-induced arthritis.  |  Staines, NA., et al. 1997. Biochem Soc Trans. 25: 661-4. PMID: 9191176
5. Versatile collagens in invertebrates.  |  Engel, J. 1997. Science. 277: 1785-6. PMID: 9324767
6. Collagen-induced arthritis, an animal model of autoimmunity.  |  Myers, LK., et al. 1997. Life Sci. 61: 1861-78. PMID: 9364191
7. The cartilage collagens: a review of their structure, organization, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic disease.  |  Cremer, MA., et al. 1998. J Mol Med (Berl). 76: 275-88. PMID: 9535561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-COL1A1 Antibody (3G3) has 179 citations in a variety of scientific publications.

Primary antibodies like Anti-COL1A1 Antibody (3G3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

COL1A1 Antibody (3G3) Specifications

Alternate Product Name: COL1A1

Product Clone Name: 3G3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1021-1108

Epitope Target: COL1A1

Epitope Species: human

Product Reactivity/Detection: Collagen α1 Type I

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 179 citations in various scientific publications

Available Conjugates/Forms for COL1A1 Antibody (3G3): N/A