COG1 Antibody (44): sc-136179

COG1 Antibody (44) is a mouse monoclonal IgG2a kappa light chain antibody that detects COG1 protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-COG1 antibody (44) is available as the non-conjugated format. COG1, or Conserved oligomeric Golgi complex subunit 1, is a crucial 980 amino acid protein that plays a vital role in the proper functioning of the Golgi apparatus. Located on the cytosolic side of the Golgi membrane, COG1 is part of a larger complex that is essential for maintaining Golgi morphology and localization, as well as facilitating intra-Golgi trafficking. The COG complex, which consists of eight protein components (COG1-8), is organized into two lobes, Lobe A and Lobe B, and is integral to the retrograde transport of vesicles. Disruptions in the COG complex can lead to significant cellular dysfunction, particularly affecting glycosylation processes, protein sorting, and overall Golgi integrity. Notably, mutations in the gene encoding COG1 are linked to congenital disorder of glycosylation type 2G, a serious inherited condition characterized by under-glycosylated serum glycoproteins, resulting in a range of clinical manifestations including immunodeficiency, dysmorphic features, coagulation disorders, psychomotor retardation, and hypotonia. COG1 (44) monoclonal antibody serves as a valuable tool for researchers studying Golgi function and related disorders.

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COG1 Antibody (44) References:

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