CNP Antibody (C-9): sc-374043

CNP Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects CNP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CNP antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. C-type natriuretic peptide (CNP) plays a crucial role in cardiovascular health, primarily functioning as a vasodilator that helps regulate blood pressure and fluid balance. CNP is predominantly expressed in the brain, where CNP is involved in the modulation of vascular tone and the inhibition of excessive cell proliferation, which is vital for maintaining homeostasis in the cardiovascular system. CNP protein is characterized by a unique 17-residue ring structure stabilized by an intramolecular disulfide bond, a feature that is essential for biological activity and interaction with specific receptors. The genes encoding the natriuretic peptides, including CNP, are located on different chromosomes, with CNP mapping to human chromosome 2q24-qter, highlighting the evolutionary divergence and functional specialization of these peptides.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CNP Antibody (C-9) References:

1. Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.  |  Tsuruzoe, K., et al. 2001. Mol Cell Biol. 21: 26-38. PMID: 11113178
2. Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC).  |  Ogawa, Y., et al. 1994. Genomics. 24: 383-7. PMID: 7698765

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CNP Antibody (C-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CNP Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CNP Antibody (C-9) Specifications

Alternate Product Name: CNP

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-115

Epitope Target: CNP

Epitope Species: human

Product Reactivity/Detection: CNP precursor and all active peptides

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CNP Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin