CNG-β3 Antibody (H-3): sc-390088
- CNG-β3 Antibody (H-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-224 mapping at the N-terminus of CNG-β3 of mouse origin
- Anti-CNG- beta 3 Antibody (H-3) is recommended for detection of CNG-β3 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-CNG- beta 3 Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for CNG-β3 Antibody (H-3) for WB applications. This reagent is now offered in a bundle with CNG-β3 Antibody (H-3) (see ordering information below).
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CNG-β3 Antibody (H-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects CNG-β3 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CNG-β3 antibody (H-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CNG-β3, also known as cyclic-nucleotide-gated cation channel beta 3, plays a crucial role in the function of cyclic nucleotide-gated (CNG) cation channels, which are essential for sensory transduction in the olfactory and visual systems. These channels are heteromeric complexes composed of principal alpha subunits and modulatory beta subunits, where the alpha subunits (CNG1-3) can form functional cation channels independently, while the beta subunits (CNG4-6) do not form channels but instead modify the properties of the channels formed by the alpha subunits. CNG-β3 is specifically activated by cyclic guanosine monophosphate (cGMP), leading to the depolarization of rod photoreceptors, which is vital for visual signal transduction. CNG-β3 is predominantly expressed in a small subset of retinal photoreceptor cells and in the testis, highlighting its importance in both vision and reproductive biology. Notably, mutations in the gene encoding CNG-β3 can result in achromatopsia, a genetic condition characterized by impaired color vision, low visual acuity, and photophobia, underscoring CNG-β3′s significance in maintaining normal visual function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CNG-β3 Antibody (H-3) References:
- Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. | Gerstner, A., et al. 2000. J Neurosci. 20: 1324-32. PMID: 10662822
- Functionally important calmodulin-binding sites in both NH2- and COOH-terminal regions of the cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit. | Peng, C., et al. 2003. J Biol Chem. 278: 24617-23. PMID: 12730238
- Achromatopsia caused by novel mutations in both CNGA3 and CNGB3. | Johnson, S., et al. 2004. J Med Genet. 41: e20. PMID: 14757870
- Progressive cone dystrophy associated with mutation in CNGB3. | Michaelides, M., et al. 2004. Invest Ophthalmol Vis Sci. 45: 1975-82. PMID: 15161866
- Functional role of hCngb3 in regulation of human cone cng channel: effect of rod monochromacy-associated mutations in hCNGB3 on channel function. | Okada, A., et al. 2004. Invest Ophthalmol Vis Sci. 45: 2324-32. PMID: 15223812
- CNGB3 mutations account for 50% of all cases with autosomal recessive achromatopsia. | Kohl, S., et al. 2005. Eur J Hum Genet. 13: 302-8. PMID: 15657609
- An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. | Sautter, A., et al. 1998. Proc Natl Acad Sci U S A. 95: 4696-701. PMID: 9539801
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CNG-β3 Antibody (H-3) | sc-390088 | 200 µg/ml | $316.00 | |||
CNG-β3 Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-526120 | 200 µg Ab; 10 µg BP | $354.00 | |||
CNG-β3 Antibody (H-3) AC | sc-390088 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CNG-β3 Antibody (H-3) HRP | sc-390088 HRP | 200 µg/ml | $316.00 | |||
CNG-β3 Antibody (H-3) FITC | sc-390088 FITC | 200 µg/ml | $330.00 | |||
CNG-β3 Antibody (H-3) PE | sc-390088 PE | 200 µg/ml | $343.00 | |||
CNG-β3 Antibody (H-3) Alexa Fluor® 488 | sc-390088 AF488 | 200 µg/ml | $357.00 | |||
CNG-β3 Antibody (H-3) Alexa Fluor® 546 | sc-390088 AF546 | 200 µg/ml | $357.00 | |||
CNG-β3 Antibody (H-3) Alexa Fluor® 594 | sc-390088 AF594 | 200 µg/ml | $357.00 | |||
CNG-β3 Antibody (H-3) Alexa Fluor® 647 | sc-390088 AF647 | 200 µg/ml | $357.00 | |||
CNG-β3 Antibody (H-3) Alexa Fluor® 680 | sc-390088 AF680 | 200 µg/ml | $357.00 | |||
CNG-β3 Antibody (H-3) Alexa Fluor® 790 | sc-390088 AF790 | 200 µg/ml | $357.00 |