Clusterin-α Antibody (78E): sc-32264

Clusterin-α Antibody (78E) is a mouse monoclonal IgG1 antibody engineered to recognize native Clusterin purified from human serum, and is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Clusterin-α, also known as apolipoprotein J (ApoJ), is a multifunctional secretory glycoprotein that plays critical roles in various physiological processes, including immune regulation, cell adhesion, lipid transportation, tissue remodeling, membrane recycling, and cell-cell interactions. Within the cell, Clusterin-α is primarily localized in the extracellular matrix where anti-Clusterin-α antibody (78E) acts as a complement lysis inhibitor, protecting cells from complement-mediated damage and maintaining immune homeostasis. Additionally, Clusterin-α is found in the cytoplasm and nucleus of cells, where Clusterin-α is involved in processes such as apoptosis regulation and cellular stress responses. This dual localization is essential for its diverse functions, as extracellular Clusterin-α facilitates interactions between cells and their environment, while intracellular Clusterin-α participates in intracellular signaling pathways and protein homeostasis. The precise cellular localization of Clusterin-α is crucial for preventing unwanted cell death, promoting cell survival, and maintaining cellular integrity under stress conditions. By specifically targeting Clusterin-α, Clusterin-α (78E) antibody enables detailed studies of distribution and interactions within different cellular compartments, providing valuable insights into involvement in pathological conditions such as cancer, where Clusterin-α is often overexpressed in advanced tumor stages, and neurodegenerative diseases like Alzheimer′s disease, where Clusterin-α influences β-amyloid aggregation and neuritic toxicity. Whether utilized in basic research to elucidate mechanisms governing Clusterin-α localization and function or in clinical diagnostics to assess expression patterns in patient samples, Clusterin-α monoclonal antibody (78E) offers reliable and precise detection, supporting advancements in understanding immune regulation, cancer biology, neurodegeneration, and the development of targeted therapeutic strategies.

The preferred Clusterin-α antibody is Clusterin-α Antibody (B-5): sc-5289.