CLPTM1 Antibody (C-2): sc-398443

CLPTM1 Antibody (C-2) is a mouse monoclonal IgG2a antibody that detects cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLPTM1 plays a crucial role in the development of the oral-facial region, and proper function is essential for normal embryonic development, particularly in preventing cleft lip and palate, which are among the most common congenital anomalies. CLPTM1 is located in the cell membrane, where CLPTM1 is involved in cellular signaling pathways that regulate cell proliferation and apoptosis. Understanding CLPTM1 localization is vital, as disruptions in CLPTM1 function can lead to developmental disorders and may also influence the response to certain chemotherapeutic agents, highlighting CLPTM1′s importance in both developmental biology and cancer research. Anti-CLPTM1 antibody (C-2) is an invaluable tool for researchers studying the molecular mechanisms underlying cleft formation and potential therapeutic targets for related conditions.

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CLPTM1 Antibody (C-2) References:

1. Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis.  |  Rossi, MR., et al. 2005. Cancer Genet Cytogenet. 161: 97-103. PMID: 16102578
2. Human cleft lip and palate fibroblasts and normal nicotine-treated fibroblasts show altered in vitro expressions of genes related to molecular signaling pathways and extracellular matrix metabolism.  |  Baroni, T., et al. 2010. J Cell Physiol. 222: 748-56. PMID: 20020508
3. A TERT-CLPTM1 locus polymorphism (rs401681) is associated with EGFR mutation in non-small cell lung cancer.  |  Lee, DH., et al. 2017. Pathol Res Pract. 213: 1340-1343. PMID: 29033187
4. Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.  |  Ge, Y., et al. 2018. Neuron. 97: 596-610.e8. PMID: 29395912
5. Genetic effects and gene-by-education interactions on episodic memory performance and decline in an aging population.  |  Smith, JA., et al. 2021. Soc Sci Med. 271: 112039. PMID: 30449520
6. Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma.  |  Inoue, K., et al. 2019. J Cancer Res Clin Oncol. 145: 851-859. PMID: 30635792
7. Regulation of GABAARs by Transmembrane Accessory Proteins.  |  Han, W., et al. 2021. Trends Neurosci. 44: 152-165. PMID: 33234346
8. Association of relative leukocyte telomere length and genetic variants in telomere-related genes (TERT, TERT-CLPTM1, TRF1, TNKS2, TRF2) with atrophic age-related macular degeneration.  |  Banevicius, M., et al. 2021. Ophthalmic Genet. 42: 189-194. PMID: 33565341
9. A lipid scramblase TMEM41B is involved in the processing and transport of GPI-anchored proteins.  |  Cao, SY., et al. 2023. J Biochem. 174: 109-123. PMID: 37279648
10. De novo CLPTM1 variants with reduced GABAA R current response in patients with epilepsy.  |  Liu, N., et al. 2023. Epilepsia. 64: 2968-2981. PMID: 37577761

The preferred CLPTM1 antibody is CLPTM1 Antibody (G-7): sc-374619.