CLP36 Antibody (D-6): sc-365143

CLP36 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects CLP36 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLP36, also known as PDLIM1, CLIM1, or Elfin, is a 329 amino acid cytoplasmic protein that plays a crucial role in the organization of the cytoskeleton by associating with actin stress fibers. CLP36 is predominantly expressed in skeletal muscle and heart tissues, with lower expression levels found in the colon, small intestine, spleen, lung, placenta, kidney, liver, thymus, and pancreas. CLP36 functions as an adaptor protein, facilitating the recruitment of other proteins to the cytoskeleton, thereby influencing cellular structure and signaling pathways. Notably, CLP36 interacts with Clik1, a kinase, and helps to localize Clik1 to α-actinin-1, promoting association with actin stress fibers. CLP36 features one PDZ domain and one LIM zinc-binding domain, which are essential for protein-protein interactions. Additionally, human CLP36 exhibits 88% sequence similarity with its rat counterpart, indicating a conserved functional role across species. With versatile applications and critical involvement in cytoskeletal dynamics, anti-CLP36 antibody (D-6) serves as an invaluable tool for researchers studying cellular architecture and signaling mechanisms.

The preferred CLP36 antibody is CLP36 Antibody (B-9): sc-393084.