Anti-Clock Antibody (C-8) is a mouse monoclonal IgG2bClock antibody, cited in 5 publications, provided at 200 µg/ml
raised against amino acids 571-846 of Clock of human origin
Anti-Clock Antibody (C-8) is recommended for detection of Clock of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-Clock Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for ChIP application (sc-271603 X, 200 µg/0.1 ml)
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Clock (C-8): sc-271603.
m-IgG2b BP-HRP is the preferred secondary detection reagent for Clock Antibody (C-8) for WB applications. This reagent is now offered in a bundle with Clock Antibody (C-8) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Clock Antibody (C-8) is a high quality monoclonal Clock antibody (also designated Clock Circadian Regulator antibody, BHLHe8 antibody, Circadian Locomoter Output Cycles Protein Kaput antibody, Class E Basic Helix-Loop-Helix Protein 8 antibody, KAT13D antibody, Clock Homolog antibody, BHLHE8 antibody, or HCLOCK antibody) suitable for the detection of the Clock protein of mouse, rat and human origin. Clock Antibody (C-8) is available as both the non-conjugated anti-Clock antibody form, as well as multiple conjugated forms of anti-Clock antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. Clock, a member of the basic-helix-loop-helix-PAS (bHLH-PAS) family of transcription factors, has also been identified as having circadian function (2,5). Mutations within the Clock gene have been shown to increase the length of the endogenous period and to cause a loss of rhythmicity of circadian oscillations. Clock contains a DNA-binding domain, a protein dimerization domain and a glutamine-rich C-terminal region, which indicates transactivation capabilities. It has been speculated that Clock may regulate circadian rhythmicity in combination with other proteins such as Per. Per is also a PAS-domain containing protein that exhibits circadian function. Highest expression of Clock is seen in the hypothalamus and the eye.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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