CLK3 Antibody (4F12): sc-134301
- CLK3 Antibody (4F12) is a mouse monoclonal IgG2b κ provided at 100 µg/ml
- raised against recombinant CLK3 protein of human origin
- recommended for detection of CLK3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CLK3 Antibody (4F12). This work is in progress.
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CLK3 Antibody (4F12) is a mouse monoclonal IgG2b antibody that detects CLK3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CLK3, also known as CDC-like kinase 3 or PHCLK3, is a 638 amino acid protein located in both the nucleus and cytoplasm, playing a crucial role in the regulation of RNA splicing. As a dual-specificity kinase, CLK3 is responsible for the ATP-dependent phosphorylation of serine- and arginine-rich splicing factor proteins, which is vital for their functional modulation and proper localization within the nucleus. This phosphorylation process is essential for the intricate regulation of gene expression, as CLK3 influences the splicing of pre-mRNA, thereby impacting the production of diverse protein isoforms necessary for various cellular functions. The presence of four isoforms of CLK3, resulting from alternative splicing, further highlights the complexity and regulatory potential of CLK3 in cellular processes. Anti-CLK3 antibody (4F12) serves as an invaluable tool for researchers exploring the dynamics of RNA splicing and the broader implications of CLK3 in cellular regulation and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLK3 Antibody (4F12) | sc-134301 | 100 µg/ml | $339.00 |