CLEC-1 Antibody (D-6): sc-393134
- CLEC-1 Antibody (D-6) is a mouse monoclonal IgG1 κ CLEC-1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 257-280 at the C-terminus of CLEC-1 of human origin
- CLEC-1 Antibody (D-6) is recommended for detection of CLEC-1 of human origin by WB, IP, IF and ELISA
- Anti-CLEC-1 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CLEC-1 Antibody (D-6) for WB applications. These reagents are now offered in bundles with CLEC-1 Antibody (D-6) (see ordering information below).
CLEC-1 Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CLEC-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLEC-1 Antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CLEC-1, a member of the C-type lectin-like receptor family, plays a crucial role in immune response by mediating pathogen recognition, particularly in dendritic and endothelial cells. This 280 amino acid single-pass type II transmembrane protein is primarily located in perinuclear compartments and requires an associated chain for proper trafficking to the cell surface, which is essential for antigen uptake. CLEC-1 includes a single carbohydrate recognition domain vital for ligand interaction, as well as a cytoplasmic immuno-receptor tyrosine-based motif important for signaling pathways. Multiple potential phosphorylation sites can modulate CLEC-1 activity and interactions, highlighting CLEC-1′s significance in regulating innate immunity and potential implications in therapeutic strategies targeting immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CLEC-1 Antibody (D-6) References:
- Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. | Colonna, M., et al. 2000. Eur J Immunol. 30: 697-704. PMID: 10671229
- A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. | Sobanov, Y., et al. 2001. Eur J Immunol. 31: 3493-503. PMID: 11745369
- Snake venom C-type lectins interacting with platelet receptors. Structure-function relationships and effects on haemostasis. | Lu, Q., et al. 2005. Toxicon. 45: 1089-98. PMID: 15876445
- Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. | Rosen, DB., et al. 2005. J Immunol. 175: 7796-9. PMID: 16339513
- Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis. | Rupp, C., et al. 2006. Cancer Immun. 6: 10. PMID: 16875435
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLEC-1 Antibody (D-6) | sc-393134 | 200 µg/ml | $316.00 | |||
CLEC-1 Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-530366 | 200 µg Ab; 10 µg BP | $354.00 | |||
CLEC-1 Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-523819 | 200 µg Ab, 40 µg BP | $354.00 | |||
CLEC-1 Antibody (D-6): m-IgG1 BP-HRP Bundle | sc-544017 | 200 µg Ab; 20 µg BP | $354.00 | |||
CLEC-1 Antibody (D-6) AC | sc-393134 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CLEC-1 Antibody (D-6) HRP | sc-393134 HRP | 200 µg/ml | $316.00 | |||
CLEC-1 Antibody (D-6) FITC | sc-393134 FITC | 200 µg/ml | $330.00 | |||
CLEC-1 Antibody (D-6) PE | sc-393134 PE | 200 µg/ml | $343.00 | |||
CLEC-1 Antibody (D-6) Alexa Fluor® 488 | sc-393134 AF488 | 200 µg/ml | $357.00 | |||
CLEC-1 Antibody (D-6) Alexa Fluor® 546 | sc-393134 AF546 | 200 µg/ml | $357.00 | |||
CLEC-1 Antibody (D-6) Alexa Fluor® 594 | sc-393134 AF594 | 200 µg/ml | $357.00 | |||
CLEC-1 Antibody (D-6) Alexa Fluor® 647 | sc-393134 AF647 | 200 µg/ml | $357.00 | |||
CLEC-1 Antibody (D-6) Alexa Fluor® 680 | sc-393134 AF680 | 200 µg/ml | $357.00 | |||
CLEC-1 Antibody (D-6) Alexa Fluor® 790 | sc-393134 AF790 | 200 µg/ml | $357.00 | |||
CLEC-1 (D-6) Neutralizing Peptide | sc-393134 P | 100 µg/0.5 ml | $68.00 |