Clca5 Antibody (A-5): sc-515682
- Clca5 Antibody (A-5) is a mouse monoclonal IgG1 κ Clca5 antibody provided at 200 µg/ml
- raised against amino acids 601-660 mapping within an internal region of Clca5 of mouse origin
- Clca5 Antibody (A-5) is recommended for detection of Clca5 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-Clca5 Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Clca5 Antibody (A-5) for WB applications. These reagents are now offered in bundles with Clca5 Antibody (A-5) (see ordering information below).
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Clca5 Antibody (A-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Clca5 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Clca5 antibody (A-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Clca5 (A-5) antibody targets a member of the calcium-activated chloride channel (CLCA) family, which plays a crucial role in regulating ion transport and fluid secretion in epithelial tissues. This function is particularly important in maintaining mucosal hydration and protecting against pathogens, making Clca5 a significant player in respiratory and gastrointestinal health. Clca5 (A-5) monoclonal antibody recognizes strong expression in the eye and spleen, suggesting involvement in immune responses and ocular physiology. Clca5′s unique expression pattern and functional role highlight potential as a therapeutic target in conditions characterized by dysregulated chloride transport, such as cystic fibrosis and other airway diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Clca5 Antibody (A-5) References:
- Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland. | Gruber, AD., et al. 1999. Am J Physiol. 276: C1261-70. PMID: 10362588
- Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis. | Hauber, HP., et al. 2003. Laryngoscope. 113: 1037-42. PMID: 12782818
- CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer. | Li, X., et al. 2004. Oncogene. 23: 1474-80. PMID: 14973555
- Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. | Hauber, HP., et al. 2004. Eur Respir J. 23: 846-50. PMID: 15218996
- Re-expression of detachment-inducible chloride channel mCLCA5 suppresses growth of metastatic breast cancer cells. | Beckley, JR., et al. 2004. J Biol Chem. 279: 41634-41. PMID: 15292178
- Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lung. | Gandhi, R., et al. 1998. J Biol Chem. 273: 32096-101. PMID: 9822685
- Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. | Gruber, AD., et al. 1998. Genomics. 54: 200-14. PMID: 9828122
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clca5 Antibody (A-5) | sc-515682 | 200 µg/ml | $322.00 | |||
Clca5 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-531468 | 200 µg Ab; 10 µg BP | $361.00 | |||
Clca5 Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-525163 | 200 µg Ab, 40 µg BP | $361.00 | |||
Clca5 Antibody (A-5): m-IgG1 BP-HRP Bundle | sc-544573 | 200 µg Ab; 20 µg BP | $361.00 | |||
Clca5 Antibody (A-5) AC | sc-515682 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Clca5 Antibody (A-5) HRP | sc-515682 HRP | 200 µg/ml | $322.00 | |||
Clca5 Antibody (A-5) FITC | sc-515682 FITC | 200 µg/ml | $336.00 | |||
Clca5 Antibody (A-5) PE | sc-515682 PE | 200 µg/ml | $349.00 | |||
Clca5 Antibody (A-5) Alexa Fluor® 488 | sc-515682 AF488 | 200 µg/ml | $364.00 | |||
Clca5 Antibody (A-5) Alexa Fluor® 546 | sc-515682 AF546 | 200 µg/ml | $364.00 | |||
Clca5 Antibody (A-5) Alexa Fluor® 594 | sc-515682 AF594 | 200 µg/ml | $364.00 | |||
Clca5 Antibody (A-5) Alexa Fluor® 647 | sc-515682 AF647 | 200 µg/ml | $364.00 | |||
Clca5 Antibody (A-5) Alexa Fluor® 680 | sc-515682 AF680 | 200 µg/ml | $364.00 | |||
Clca5 Antibody (A-5) Alexa Fluor® 790 | sc-515682 AF790 | 200 µg/ml | $364.00 |