claudin-6 Antibody (A-4): sc-393671

claudin-6 Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects claudin-6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-claudin-6 antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. claudin-6 plays a crucial role in forming tight junctions, which are essential for maintaining epithelial and endothelial barrier integrity. These tight junctions regulate paracellular transport, ensuring substances can pass between cells in a controlled manner, vital for processes such as nutrient absorption and maintaining homeostasis. claudin-6, like other claudin family members, consists of four transmembrane domains and two extracellular loops, contributing to tight junction structural framework. Specific expression of claudin-6 in various tissues suggests distinct roles in different cellular contexts, influencing permeability and signaling pathways. Understanding claudin-6 function and regulation is important for elucidating potential implications in health and disease, particularly in conditions where tight junction integrity is compromised.

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claudin-6 Antibody (A-4) References:

1. Transmembrane proteins in the tight junction barrier.  |  Fanning, AS., et al. 1999. J Am Soc Nephrol. 10: 1337-45. PMID: 10361874
2. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells.  |  Morita, K., et al. 1999. J Cell Biol. 147: 185-94. PMID: 10508865
3. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein.  |  Fujita, K., et al. 2000. FEBS Lett. 476: 258-61. PMID: 10913624
4. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut.  |  Rahner, C., et al. 2001. Gastroenterology. 120: 411-22. PMID: 11159882
5. Retinoid X receptor alpha and retinoic acid receptor gamma mediate expression of genes encoding tight-junction proteins and barrier function in F9 cells during visceral endodermal differentiation.  |  Kubota, H., et al. 2001. Exp Cell Res. 263: 163-72. PMID: 11161715
6. The roles of claudin superfamily proteins in paracellular transport.  |  Heiskala, M., et al. 2001. Traffic. 2: 93-8. PMID: 11247307
7. Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions.  |  Nishiyama, R., et al. 2001. J Biol Chem. 276: 35571-80. PMID: 11466322
8. Claudin-6 is down-regulated in gastric cancer and its potential pathway.  |  Lu, YZ., et al. 2020. Cancer Biomark. 28: 329-340. PMID: 32390606
9. Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review).  |  Du, H., et al. 2021. Mol Med Rep. 24: PMID: 34296304
10. Preclinical Efficacy of the Antibody-Drug Conjugate CLDN6-23-ADC for the Treatment of CLDN6-Positive Solid Tumors.  |  McDermott, MSJ., et al. 2023. Clin Cancer Res. 29: 2131-2143. PMID: 36884217
11. NK-92MI Cells Engineered with Anti-claudin-6 Chimeric Antigen Receptors in Immunotherapy for Ovarian Cancer.  |  Li, J., et al. 2024. Int J Biol Sci. 20: 1578-1601. PMID: 38481806
12. Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer (Review).  |  Katoh, M. and Katoh, M. 2024. Int J Mol Med. 54: PMID: 39301632

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-claudin-6 Antibody (A-4) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-claudin-6 Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

claudin-6 Antibody (A-4) Specifications

Alternate Product Name: claudin-6

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 191-220

Epitope Target: claudin-6

Epitope Species: human

Product Reactivity/Detection: claudin-6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for claudin-6 Antibody (A-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin