claudin-19 Antibody (D-9): sc-365690

Claudin-19 Antibody (D-9) is a mouse monoclonal IgG2a antibody that detects claudin-19 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Claudin-19 is a crucial member of the claudin family, consisting of 224 amino acids and characterized as a multi-pass membrane protein that plays a significant role in the formation and maintenance of tight junctions, which are essential for regulating paracellular transport and maintaining epithelial barrier integrity. Claudin-19 is primarily localized in the tight junctions of epithelial cells, where claudin-19 contributes to the selective permeability of the epithelial barrier, allowing for the controlled passage of ions and small molecules while preventing the leakage of larger solutes. This localization is vital for maintaining homeostasis in various tissues, particularly in the kidneys, where claudin-19 is involved in the reabsorption of magnesium. Notably, mutations in the gene encoding claudin-19 can lead to hypomagnesemia renal with ocular involvement (HOMGO), a condition that underscores the importance of claudin-19 in renal function and ocular health. Anti-claudin-19 antibody (D-9) is an invaluable tool for researchers studying tight junction dynamics, renal physiology, and related pathologies.

The preferred claudin-19 antibody is claudin-19 Antibody (C-5): sc-365967.