claudin-19 Antibody (C-5): sc-365967
- claudin-19 Antibody (C-5) is a mouse monoclonal IgG1 κ claudin-19 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 160-224 mapping at the C-terminus of claudin-19 of human origin
- claudin-19 Antibody (C-5) is recommended for detection of claudin-19 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-claudin-19 Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for claudin-19 Antibody (C-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with claudin-19 Antibody (C-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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claudin-19 Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects claudin-19 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). claudin-19 (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. claudin-19, a 224 amino acid multi-pass membrane protein, plays a crucial role in forming tight junctions, which are essential for maintaining epithelial and endothelial barrier integrity. These tight junctions regulate paracellular transport, ensuring selective permeability and maintaining homeostasis within tissues. claudin-19 is particularly important in the renal system, where anti-claudin-19 antibody (C-5) contributes to ion transport regulation and is involved in hypomagnesemia renal with ocular involvement (HOMGO), a condition caused by defects in the gene encoding claudin-19. HOMGO is characterized by low magnesium levels, high calcium excretion, and kidney calcification, highlighting claudin-19′s significance in renal health. claudin-19 expression is tightly regulated and varies across different tissues, underscoring claudin-19′s potential as a biomarker for various diseases and importance in therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
claudin-19 Antibody (C-5) References:
- Transmembrane proteins in the tight junction barrier. | Fanning, AS., et al. 1999. J Am Soc Nephrol. 10: 1337-45. PMID: 10361874
- Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. | Fujita, K., et al. 2000. FEBS Lett. 476: 258-61. PMID: 10913624
- Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. | Rahner, C., et al. 2001. Gastroenterology. 120: 411-22. PMID: 11159882
- The roles of claudin superfamily proteins in paracellular transport. | Heiskala, M., et al. 2001. Traffic. 2: 93-8. PMID: 11247307
- Molecular structure of tight junctions and their role in epithelial transport. | Anderson, JM. 2001. News Physiol Sci. 16: 126-30. PMID: 11443232
- Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. | Nishiyama, R., et al. 2001. J Biol Chem. 276: 35571-80. PMID: 11466322
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
claudin-19 Antibody (C-5) | sc-365967 | 200 µg/ml | $316.00 | |||
claudin-19 Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-522446 | 200 µg Ab, 40 µg BP | $354.00 | |||
claudin-19 Antibody (C-5) AC | sc-365967 AC | 500 µg/ml, 25% agarose | $416.00 | |||
claudin-19 Antibody (C-5) HRP | sc-365967 HRP | 200 µg/ml | $316.00 | |||
claudin-19 Antibody (C-5) FITC | sc-365967 FITC | 200 µg/ml | $330.00 | |||
claudin-19 Antibody (C-5) PE | sc-365967 PE | 200 µg/ml | $343.00 | |||
claudin-19 Antibody (C-5) Alexa Fluor® 488 | sc-365967 AF488 | 200 µg/ml | $357.00 | |||
claudin-19 Antibody (C-5) Alexa Fluor® 546 | sc-365967 AF546 | 200 µg/ml | $357.00 | |||
claudin-19 Antibody (C-5) Alexa Fluor® 594 | sc-365967 AF594 | 200 µg/ml | $357.00 | |||
claudin-19 Antibody (C-5) Alexa Fluor® 647 | sc-365967 AF647 | 200 µg/ml | $357.00 | |||
claudin-19 Antibody (C-5) Alexa Fluor® 680 | sc-365967 AF680 | 200 µg/ml | $357.00 | |||
claudin-19 Antibody (C-5) Alexa Fluor® 790 | sc-365967 AF790 | 200 µg/ml | $357.00 |