CKR-5 Antibody (E-6): sc-55484

CKR-5 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects CKR-5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CKR-5, a member of the C-C chemokine receptor family, plays a crucial role in the immune response by acting as a receptor for various chemokines, which are essential for the chemotaxis of immune cells like T cells and monocytes to sites of inflammation. This receptor is particularly significant as a coreceptor for HIV, facilitating viral entry into host cells. The interaction between CKR-5 and the HIV envelope protein is vital for the virus′s ability to infect macrophages, which are key players in the immune system. Understanding the structure and function of CKR-5 is important not only for elucidating its role in immune responses but also for developing therapeutic strategies targeting HIV infection. Anti-CKR-5 antibody (E-6) is an invaluable tool for researchers studying the dynamics of immune cell migration and the mechanisms of viral pathogenesis.

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CKR-5 Antibody (E-6) References:

1. Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.  |  Dogo-Isonagie, C., et al. 2012. J Biol Chem. 287: 15076-86. PMID: 22403408
2. CCR5 plays important roles in hepatitis B infection.  |  Sanchooli, J., et al. 2014. Viral Immunol. 27: 2-6. PMID: 24405101
3. Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance.  |  Lei, H., et al. 2016. Sci Rep. 6: 18839. PMID: 26740279
4. Recent updates for designing CCR5 antagonists as anti-retroviral agents.  |  Shah, HR. and Savjani, JK. 2018. Eur J Med Chem. 147: 115-129. PMID: 29425816
5. HIV Protease Inhibitor Ritonavir Impairs Endothelial Function Via Reduction in Adipose Mass and Endothelial Leptin Receptor-Dependent Increases in NADPH Oxidase 1 (Nox1), C-C Chemokine Receptor Type 5 (CCR5), and Inflammation.  |  Bruder-Nascimento, T., et al. 2020. J Am Heart Assoc. 9: e018074. PMID: 33003981
6. Computational study of the structural ensemble of CC chemokine receptor type 5 (CCR5) and its interactions with different ligands.  |  Goode-Romero, G. and Dominguez, L. 2022. PLoS One. 17: e0275269. PMID: 36251708
7. Therapeutic Perspectives of HIV-Associated Chemokine Receptor (CCR5 and CXCR4) Antagonists in Carcinomas.  |  González-Arriagada, WA., et al. 2022. Int J Mol Sci. 24: PMID: 36613922
8. Ligand-Dependent Mechanisms of CC Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics.  |  Gu, S., et al. 2024. bioRxiv.. PMID: 37961097
9. Blockade of CCR5+ T Cell Accumulation in the Tumor Microenvironment Optimizes Anti-TGF-β/PD-L1 Bispecific Antibody.  |  Yi, M., et al. 2024. Adv Sci (Weinh). 11: e2408598. PMID: 39303165
10. Evaluation of C-C Motif Chemokine Receptor 5 (CCR5) as a Sample Adequacy Control in HPV Molecular Diagnostics.  |  Njoku, RC., et al. 2024. Diagnostics (Basel). 14: PMID: 39410598

The preferred CKR-5 antibody is CKR-5 Antibody (D-6): sc-17833.