CKR-3 Antibody (5E8): sc-32777
- CKR-3 Antibody (5E8) is a mouse monoclonal IgG2b κ CKR-3 antibody provided at 200 µg/ml
- raised against mouse B cell lymphoma L1.2 transfectants expressing CKR-3 of human origin
- CKR-3 Antibody (5E8) is recommended for detection of CKR-3 of human origin by WB, IP and FCM
- Anti-CKR-3 Antibody (5E8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for CKR-3 Antibody (5E8) for WB applications. These reagents are now offered in bundles with CKR-3 Antibody (5E8) (see ordering information below).
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CKR-3 Antibody (5E8) is a mouse monoclonal IgG2b kappa light chain antibody that detects the CKR-3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-CKR-3 antibody (5E8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CKR-3, also known as C-C chemokine receptor type 3 or CCR3, is a 355 amino acid multi-pass membrane protein that plays a crucial role in the immune response by mediating the chemotaxis of eosinophils, neutrophils, and monocytes to sites of inflammation. This receptor is particularly important because CKR-3 interacts with several chemokines, such as MCP-3 and MCP-4, which influence intracellular calcium levels and signal transduction pathways within the cell. CKR-3′s ability to facilitate the migration of immune cells is vital for mounting an effective response to infections and inflammatory conditions. CKR-3 has been implicated in various pathological processes, including asthma and other allergic responses, making CKR-3 a significant target for therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CKR-3 Antibody (5E8) References:
- Pillars article: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 1996. 272: 872-877. | Feng, Y., et al. 2011. J Immunol. 186: 6076-81. PMID: 21597040
- Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. | Schweickart, VL., et al. 1994. Genomics. 23: 643-50. PMID: 7851893
- Identification of a major co-receptor for primary isolates of HIV-1. | Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
- HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. | Dragic, T., et al. 1996. Nature. 381: 667-73. PMID: 8649512
- CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. | Alkhatib, G., et al. 1996. Science. 272: 1955-8. PMID: 8658171
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. | Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. | Doranz, BJ., et al. 1996. Cell. 85: 1149-58. PMID: 8674120
- Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. | Baba, M., et al. 1997. J Biol Chem. 272: 14893-8. PMID: 9169459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CKR-3 Antibody (5E8) | sc-32777 | 200 µg/ml | $316.00 | |||
CKR-3 Antibody (5E8): m-IgG Fc BP-HRP Bundle | sc-525539 | 200 µg Ab; 10 µg BP | $354.00 | |||
CKR-3 Antibody (5E8): m-IgG2b BP-HRP Bundle | sc-549575 | 200 µg Ab; 10 µg BP | $354.00 | |||
CKR-3 Antibody (5E8) AC | sc-32777 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CKR-3 Antibody (5E8) HRP | sc-32777 HRP | 200 µg/ml | $316.00 | |||
CKR-3 Antibody (5E8) FITC | sc-32777 FITC | 200 µg/ml | $330.00 | |||
CKR-3 Antibody (5E8) PE | sc-32777 PE | 200 µg/ml | $343.00 | |||
CKR-3 Antibody (5E8) Alexa Fluor® 488 | sc-32777 AF488 | 200 µg/ml | $357.00 | |||
CKR-3 Antibody (5E8) Alexa Fluor® 546 | sc-32777 AF546 | 200 µg/ml | $357.00 | |||
CKR-3 Antibody (5E8) Alexa Fluor® 594 | sc-32777 AF594 | 200 µg/ml | $357.00 | |||
CKR-3 Antibody (5E8) Alexa Fluor® 647 | sc-32777 AF647 | 200 µg/ml | $357.00 | |||
CKR-3 Antibody (5E8) Alexa Fluor® 680 | sc-32777 AF680 | 200 µg/ml | $357.00 | |||
CKR-3 Antibody (5E8) Alexa Fluor® 790 | sc-32777 AF790 | 200 µg/ml | $357.00 |